|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
The current meta- analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer.
|
25773837 |
2015 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The current meta- analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer.
|
25773837 |
2015 |
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer (P value = 0.047).
|
24383053 |
2013 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer (P value = 0.047).
|
24383053 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant evidence for association with prostate cancer risk for both the M9V and D175G variants was observed in the Tasmanian prostate cancer dataset.
|
18537123 |
2008 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Significant evidence for association with prostate cancer risk for both the M9V and D175G variants was observed in the Tasmanian prostate cancer dataset.
|
18537123 |
2008 |
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, prostate cancer was not related to AMACR gene variants; however, risks for prostate cancer were significantly reduced among regular ibuprofen users who carried allele variants at four nsSNP loci (M9V, D175G, S201L, and K277E; all P(trend) < 0.05) or carried the TGTGCG haplotype (OR = 0.65; 95% CI 0.44-0.97).
|
17680641 |
2007 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, prostate cancer was not related to AMACR gene variants; however, risks for prostate cancer were significantly reduced among regular ibuprofen users who carried allele variants at four nsSNP loci (M9V, D175G, S201L, and K277E; all P(trend) < 0.05) or carried the TGTGCG haplotype (OR = 0.65; 95% CI 0.44-0.97).
|
17680641 |
2007 |
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
Furthermore, the AMACR sequence variants strongly cosegregate with CaP in HPC families (log of odds = 3.78; P = 0.00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008).
|
12438241 |
2002 |
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Furthermore, the AMACR sequence variants strongly cosegregate with CaP in HPC families (log of odds = 3.78; P = 0.00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008).
|
12438241 |
2002 |
|
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Using a significance threshold of FDR < 0.1, association was detected for rs10941112 (p = 2.1 × 10<sup>-5</sup> ; q-value = 0.073) in AMACR, a gene involved in fatty acid metabolism and previously implicated in schizophrenia, with significant cis effects on gene expression (p = 5.5 × 10<sup>-4</sup> ), including brain tissue data from the Genotype-Tissue Expression project (minimum p = 6.0 × 10<sup>-5</sup> ).
|
28902459 |
2017 |
|
Schizophrenia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The G-C-G haplotype of rs2278008-rs2287939-rs10941112 revealed the most significant association with schizophrenia (P = 4.25 × 10-6, OR = 2.96; 95% CI: 1.85-4.76) in male subjects.
|
20875727 |
2010 |
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regular ibuprofen users who were homozygous for the variant allele at either M9V or D175G were at reduced risk for adenoma (both P(interaction) < 0.05).
|
17684125 |
2007 |