|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene.
|
20739100 |
2011 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
CLU-rs11136000-G associated with worse baseline memory and incident MCI/LOAD.
|
25189118 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD).
|
24806679 |
2014 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls.
|
22015308 |
2012 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several genome-wide association studies have found that the rs11136000 polymorphism of the C allele (CLU-C) is associated with the risk for developing late-onset Alzheimer's disease (LOAD).
|
27396407 |
2016 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals.
|
22296908 |
2011 |
|
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p = 0.009 with, and p = 0.03 without, APOE adjustment) and CLU (rs11136000, p = 0.023 with, and p = 0.008 without, APOE adjustment), with weaker support for CR1.
|
21379329 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, we identified that the minor allele variant of rs11136000 significantly decrease AD risk in Caucasian ethnicity using the allele, dominant and recessive model.
|
30038359 |
2018 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011).
|
21422520 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies identify rs11136000 in the CLU gene, which codes for Apolipoprotein J/Clusterin, as a significant risk variant for Alzheimer's disease (AD).
|
25496871 |
2015 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified a significant association between rs1</span>1136000 and AD with the allele model (P = 2.00 × 10(-4)) and the dominant model (P = 5.00 × 10(-3)).
|
23892938 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk.
|
22506010 |
2012 |