Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Similarly, we identified that the minor allele variant of rs11136000 significantly decrease AD risk in Caucasian ethnicity using the allele, dominant and recessive model.
|
30038359 |
2018 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011).
|
21422520 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies identify rs11136000 in the CLU gene, which codes for Apolipoprotein J/Clusterin, as a significant risk variant for Alzheimer's disease (AD).
|
25496871 |
2015 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified a significant association between rs1</span>1136000 and AD with the allele model (P = 2.00 × 10(-4)) and the dominant model (P = 5.00 × 10(-3)).
|
23892938 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk.
|
22506010 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in MTHFR (rs1801133), PICALM (3851719), CLU (rs11136000), and CR1 (rs6701713) are associated with AD.
|
25359311 |
2015 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD).
|
24578178 |
2015 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU).
|
21397462 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Plasma clusterin levels and the rs11136000 genotype in individuals with mild cognitive impairment and Alzheimer's disease.
|
24117116 |
2013 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD.
|
26899953 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined the effect of the novel Alzheimer's disease (AD) risk variant rs11136000 single nucleotide polymorphism in the clusterin gene (CLU) on longitudinal changes in resting state regional cerebral blood flow (rCBF) during normal aging and investigated its influence on cognitive decline in presymptomatic stages of disease progression.
|
22795969 |
2013 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients.
|
28631188 |
2018 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Clusterin (rs11136000) was associated with Alzheimer's disease in Chinese Han population.
|
22296908 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The significant association between rs11136000 and AD in the pooled population was found under all the models.
|
29396813 |
2018 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) association analysis indicated the common AD risk association (GWA SNP rs11136000, p = 0.013) in the 3 combined datasets could not be explained by the presence of the rare coding variations we identified.
|
22248099 |
2012 |
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene.
|
20739100 |
2011 |
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
Alzheimer Disease, Late Onset
|
|
0.100 |
GeneticVariation
|
BEFREE |
CLU-rs11136000-G associated with worse baseline memory and incident MCI/LOAD.
|
25189118 |
2015 |