|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
We identified a synonymous SNP rs1137070 showing significant associations with major depressive disorder (p = 0.00067, OR = 1.263 for T allele) and schizophrenia (p = 0.0039, OR = 1.225 for T allele) as well as a broad spectrum of psychiatric phenotype (p = 0.000066, OR = 1.218 for T allele) in both males and females.
|
26227907 |
2016 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Quantitative real-time polymerase chain reaction analysis showed that overall relative quantity of MAOA messenger RNA was significantly higher in patients with MDD than in control subjects (fold change = 5.28, p = 1.7 × 10⁻⁷) and that in the male subjects carrying the VNTR-L, rs1465107-A, rs6323-G, rs2072743-A, or rs1137070-T alleles, expression of MAOA messenger RNA was significantly higher in the patient group than in the control group.
|
20691428 |
2010 |
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among the females, an association was found between MAOA polymorphisms and severe MDD (P=0.041 for uVNTR and 0.017 for EcoRV (rs1137070), respectively).
|
19224413 |
2009 |
|
Nicotine Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that MAOA rs1137070 contributes to the susceptibility to nicotine dependence through its influence on brain circuits involved in reward and attention, and interacts with smoking in the progression.
|
30456877 |
2019 |
|
heroin abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggest that the low activity-related C allele of MAOA rs1137070 is associated with an increase in the sensitivity to heroin addiction and the damaging effects of heroin abuse on cognition and the salience network.
|
28345608 |
2017 |
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior.
|
28345608 |
2017 |
|
Heroin Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Heroin addiction and the rs1137070 variant interactively altered measures of GMV in the anterior cingulate cortex, orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function.
|
28345608 |
2017 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified a synonymous SNP rs1137070 showing significant associations with major depressive disorder (p = 0.00067, OR = 1.263 for T allele) and schizophrenia (p = 0.0039, OR = 1.225 for T allele) as well as a broad spectrum of psychiatric phenotype (p = 0.000066, OR = 1.218 for T allele) in both males and females.
|
26227907 |
2016 |
|
Unipolar Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified a synonymous SNP rs1137070 showing significant associations with major depressive disorder (p = 0.00067, OR = 1.263 for T allele) and schizophrenia (p = 0.0039, OR = 1.225 for T allele) as well as a broad spectrum of psychiatric phenotype (p = 0.000066, OR = 1.218 for T allele) in both males and females.
|
26227907 |
2016 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The relationships in the polymorphisms of rs1137070 C>T and rs1799836 A>G in the MAO gene with PD susceptibility observed in our meta-analyses support the view that the MAO gene may play an important role in the development of PD.
|
25066260 |
2014 |
|
Hyperuricemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that MAOA enzyme activity by rs1137070 allele was associated with hyperuricemia and gout (P for trend = 1.53 x 10(-6) vs. wild-type allele).
|
19915868 |
2010 |