|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001).
|
29893028 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, our data suggest that a combination of polymorphism in the LEP gene 3' flanking region, and Lys109Arg, Lys656Asn variants in LEPR gene is associated with obesity in Chinese Han population.
|
24308887 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele dosage analysis of rs2069845, rs1137100, and rs3801266 revealed that children with five to six risk alleles had an approximately four times increased risk of obesity than children with less than two risk alleles (P = 1.2 × 10(-7)).
|
22228719 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus.
|
22746211 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects.
|
22028824 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that c.517A→G and Lys(109)Arg contribute to the variation in anthropometric obesity phenotype indicators observed among Black African and mixed-ancestry South African learners.
|
21921635 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity.
|
20183928 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.
|
31128439 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present meta-analysis did not detect significant genetic associations between LEPR Q223R and K109R polymorphisms and T2D risk.
|
29293570 |
2018 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multivariate analysis confirmed that leptin, soluble leptin receptor, free leptin index and G109 (R109) allele of the LEPR gene K109R polymorphism are risk factors for breast cancer.
|
28190851 |
2017 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multivariate analysis confirmed that leptin, soluble leptin receptor, free leptin index and G109 (R109) allele of the LEPR gene K109R polymorphism are risk factors for breast cancer.
|
28190851 |
2017 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These findings suggested that the LEPR K109R(rs1137100) genetic polymorphism may decrease the susceptibility in breast cancer, especially in the additive genetic model.
|
25261678 |
2014 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
These findings suggested that the LEPR K109R(rs1137100) genetic polymorphism may decrease the susceptibility in breast cancer, especially in the additive genetic model.
|
25261678 |
2014 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
And significantly elevated breast cancer risk was associated with LEPR rs1137100 polymorphism for allele contrast (OR = 0.666, 95 % CI = 0.603-0.720) and homozygote codominant models (OR = 0.344, 95 % CI = 0.282-0.421).
|
22983835 |
2012 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And significantly elevated breast cancer risk was associated with LEPR rs1137100 polymorphism for allele contrast (OR = 0.666, 95 % CI = 0.603-0.720) and homozygote codominant models (OR = 0.344, 95 % CI = 0.282-0.421).
|
22983835 |
2012 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Overall, the results showed null significant association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, or PON1 Q192R polymorphism and breast cancer risk; however, PON1 L55M was significantly associated with breast cancer risk overall (MM vs. LL: OR = 2.16; 95% CI, 1.76-2.66).
|
21887553 |
2011 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Overall, the results showed null significant association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, or PON1 Q192R polymorphism and breast cancer risk; however, PON1 L55M was significantly associated with breast cancer risk overall (MM vs. LL: OR = 2.16; 95% CI, 1.76-2.66).
|
21887553 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP; 19G>A) gene and its receptor (LEPR; Q223R and K109R) are associated with birth weight and adult metabolic risk factors for type 2 diabetes in twins.
|
18490929 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moderate/severe periodontitis patients with rs1501299-GG and rs1137100-GG have the highest T2DM risk after adjusting for age, gender, BMI, WHR, smoking status, alcohol consumption, economic status, and hypertension (AOR = 20.39, 95%CI: 2.64-157.26).
|
31128439 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
LEPR K109R might be a susceptible factor for NAFLD in Southeast Asian population.
|
29974828 |
2018 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
To evaluate the potential contribution of LEPrs2167270(19 G/A), LEPRrs1137100(326 A/G) and ADIPOQrs1501299(276 G/T) gene polymorphisms in psoriasis susceptibility and their influence in epicardial adipose tissue and abdominal visceral fat volume and subclinical atherosclerosis in severe psoriasis patients.
|
26123401 |
2015 |