Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotype combination of LEP c.-2548G>A and LEPR p.Q223R</span> variants was related to a 58% increase in obesity risk.
|
18273796 |
2007 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that LEP G-2548A and LEPR Q223R SNPs may not be considered as genetic risk factors for obesity in a sample of Romanian population.
|
19913498 |
2010 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others.
|
26064921 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the impact of mothers' and newborns' fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother-newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029).
|
27930556 |
2016 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women.
|
28416193 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we hypothesized that the LEP-rs7799039 and LEPR-rs1137101 SNPs are related to the risk of pre-pregnancy overweight/obesity (body mass index ≥25 kg/m<sup>2</sup>) as well as to excessive gestational weight gain (GWG) and high concentrations of leptin throughout pregnancy.
|
29241578 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity.
|
26255942 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, our results support the hypothesis that Gln223Arg</span> polymorphism of LEPR in Mexican adolescents is associated with haemodynamic and metabolic disturbances related to obesity.
|
15660115 |
2005 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study showed that LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
|
22734460 |
2012 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity.
|
29893028 |
2018 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant difference in LEPR p.Q223</span>R polymorphism frequency when comparing obese and lean subjects, with an odds ratio of 1.92 and a 95% confidence interval of 1.15-3.22 (P = 0.013).
|
16788891 |
2006 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribution between obese and controls. rs1137101 variant of leptin receptor and fasting leptin level are correlated with overweight and obesity in Saudi children.
|
29412799 |
2018 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overweight-obese subjects had significantly higher frequencies of the Arg223 allele and the Arg223 homozygous allele of Gln223Arg and the Asn656 allele of Lys656Asn compared to lean subjects.
|
18716356 |
2008 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of two obesity-related gene polymorphisms LEPG2548A rs7799039 and LEPRQ223R rs1137101 with the risk of breast cancer.
|
28938640 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, the results of our study show that the LEPR Q223R polymorphism may be associated with obesity in women with a psychotic disorder treated with atypical antipsychotic drugs and stress the importance of stratification for gender when investigating the role of variations of the LEP- and LEPR genes on the metabolic side effects of antipsychotic medications.
|
19142102 |
2009 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The inverse association between the Q223R polymorphism and obesity</span> (OR = 0.62; 95% CI: 0.39-0.99) remained significant even after additional adjustment for education, tobacco smoking, alcohol, physical activity, origin of the obese patient, and the -2548G > A polymorphism in the LEP gene (OR = 0.54; 95% CI: 0.32-0.89).
|
17031518 |
2006 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair insertion/deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg.
|
17124363 |
2007 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the LEPR gene Q223R polymorphism has an association with waist and hip circumferences in obese group but no direct association with obesity although there is a significant influence on lipid profile both in obese and non-obese subjects.
|
23954230 |
2013 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In children with obesity we did not observe association of the LEPR Gln223Arg gene polymorphism with obesity, leptin, insulin resistance, and metabolic abnormalities.
|
20156757 |
2009 |