|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population.
|
11549688 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity-related genetic factors including common polymorphisms in the leptin gene (LEP A19G and G-2548A) and its receptor (LEPR Q223R) were investigated in DNA available for 376 patients and 805 controls.
|
15159310 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL.
|
15337805 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To conclude, our results support the hypothesis that Gln223Arg</span> polymorphism of LEPR in Mexican adolescents is associated with haemodynamic and metabolic disturbances related to obesity.
|
15660115 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity.
|
16571841 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant difference in LEPR p.Q223</span>R polymorphism frequency when comparing obese and lean subjects, with an odds ratio of 1.92 and a 95% confidence interval of 1.15-3.22 (P = 0.013).
|
16788891 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The inverse association between the Q223R polymorphism and obesity</span> (OR = 0.62; 95% CI: 0.39-0.99) remained significant even after additional adjustment for education, tobacco smoking, alcohol, physical activity, origin of the obese patient, and the -2548G > A polymorphism in the LEP gene (OR = 0.54; 95% CI: 0.32-0.89).
|
17031518 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair insertion/deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg.
|
17124363 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotype combination of LEP c.-2548G>A and LEPR p.Q223R</span> variants was related to a 58% increase in obesity risk.
|
18273796 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overweight-obese subjects had significantly higher frequencies of the Arg223 allele and the Arg223 homozygous allele of Gln223Arg and the Asn656 allele of Lys656Asn compared to lean subjects.
|
18716356 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, the results of our study show that the LEPR Q223R polymorphism may be associated with obesity in women with a psychotic disorder treated with atypical antipsychotic drugs and stress the importance of stratification for gender when investigating the role of variations of the LEP- and LEPR genes on the metabolic side effects of antipsychotic medications.
|
19142102 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that LEP G-2548A and LEPR Q223R SNPs may not be considered as genetic risk factors for obesity in a sample of Romanian population.
|
19913498 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In children with obesity we did not observe association of the LEPR Gln223Arg gene polymorphism with obesity, leptin, insulin resistance, and metabolic abnormalities.
|
20156757 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.
|
20183928 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The LEPR Q223R polymorphism may be a risk factor for obesity in women with a psychotic disorder treated with atypical antipsychotic drugs.
|
21510767 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study showed that LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
|
22734460 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the LEPR gene Q223R polymorphism has an association with waist and hip circumferences in obese group but no direct association with obesity although there is a significant influence on lipid profile both in obese and non-obese subjects.
|
23954230 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the LEP G2548A polymorphism is not a relevant obesity marker and that the LEPR 668A/G polymorphism may be related to obesity in a Turkish population.
|
24319309 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) in leptin gene LEP (A19G and G2548A) and leptin receptor gene LEPR (K109R and Q223R) and their association with fasting plasma leptin level (PLL) and obesity in a Malaysian suburban population in Kampar, Perak.
|
24947733 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others.
|
26064921 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity.
|
26255942 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the impact of mothers' and newborns' fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother-newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029).
|
27930556 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between overweight/obesity and polymorphisms in the LEP (rs7799039), LEP receptor (LEPR; rs1137101), and ADIPOQ genes (rs2241766, rs1501299) with the response to breast cancer treatment in Mexican women.
|
28416193 |
2017 |