|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two polymorphisms of ERCC1, T19007C (rs11615) and C8092A (rs3212986), have been reported to affect both the carcinogenesis and the survival of the patients who received platinum-based chemotherapy, but the mechanism by which these polymorphisms influence the survival is unclear.
|
19361884 |
2010 |
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
NER ERCC1 rs11615C>T and ERCC2 rs13181T>G polymorphisms are useful prognostic factors in oxaliplatin-based treatment of gastric and colorectal cancer.
|
21278243 |
2011 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
NER ERCC1 rs11615C>T and ERCC2 rs13181T>G polymorphisms are useful prognostic factors in oxaliplatin-based treatment of gastric and colorectal cancer.
|
21278243 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in ERCC1 gene, T19007C (rs11615) and C8092A (rs3212986), reportedly predict to affect the mRNA of ERCC1 in non-small cell lung cancer (NSCLC).
|
21553053 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, a significant effect of SNPs in nucleotide excision repair pathway on lung cancer survival was observed among 185 stages III-IV patients treated with platinum-based chemotherapy without surgical operation: XPC rs2228000 (Ala499Val; P = 0.002) and ERCC1 rs11615 (Asn118Asn; P = 0.012).
|
21739480 |
2012 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, a significant effect of SNPs in nucleotide excision repair pathway on lung cancer survival was observed among 185 stages III-IV patients treated with platinum-based chemotherapy without surgical operation: XPC rs2228000 (Ala499Val; P = 0.002) and ERCC1 rs11615 (Asn118Asn; P = 0.012).
|
21739480 |
2012 |
|
Malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, a significant effect of SNPs in nucleotide excision repair pathway on lung cancer survival was observed among 185 stages III-IV patients treated with platinum-based chemotherapy without surgical operation: XPC rs2228000 (Ala499Val; P = 0.002) and ERCC1 rs11615 (Asn118Asn; P = 0.012).
|
21739480 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We investigated the association of three DNA repair gene polymorphisms - Asn118Asn in ERCC1 (rs11615), Lys751Gln in ERCC2 (rs13181), and Asp1104His in ERCC5 (rs17655) - with the progression-free survival of 85 patients treated with platinum-based chemotherapy after surgery for NSCLC.
|
21766907 |
2011 |
|
Osteosarcoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Excision repair cross-complementing (ERCC) group 2 (XPD; rs13181 and rs1799793), group 5 (XPG; rs17655) and group 1 (XPA; rs3212986 and rs11615) polymorphisms were analyzed in a group of 130 homogenously treated patients with high-grade osteosarcoma, for association with event-free survival (EFS), using the Kaplan-Meier plots and log-rank test.
|
21826087 |
2012 |
|
Osteosarcoma of bone
|
|
0.100 |
GeneticVariation
|
BEFREE |
Excision repair cross-complementing (ERCC) group 2 (XPD; rs13181 and rs1799793), group 5 (XPG; rs17655) and group 1 (XPA; rs3212986 and rs11615) polymorphisms were analyzed in a group of 130 homogenously treated patients with high-grade osteosarcoma, for association with event-free survival (EFS), using the Kaplan-Meier plots and log-rank test.
|
21826087 |
2012 |
|
Childhood Osteosarcoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Excision repair cross-complementing (ERCC) group 2 (XPD; rs13181 and rs1799793), group 5 (XPG; rs17655) and group 1 (XPA; rs3212986 and rs11615) polymorphisms were analyzed in a group of 130 homogenously treated patients with high-grade osteosarcoma, for association with event-free survival (EFS), using the Kaplan-Meier plots and log-rank test.
|
21826087 |
2012 |
|
Malignant neoplasm of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms of ERCC1 (rs11615) could therefore be applied to further individualize therapy in esophageal cancer.
|
21956434 |
2012 |
|
Esophageal Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms of ERCC1 (rs11615) could therefore be applied to further individualize therapy in esophageal cancer.
|
21956434 |
2012 |
|
Esophageal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms of ERCC1 (rs11615) could therefore be applied to further individualize therapy in esophageal cancer.
|
21956434 |
2012 |
|
Adenocarcinoma Of Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of ERCC1 (rs11615) gene polymorphisms reveals a significant correlation with response and survival in patients with adenocarcinoma of the esophagus treated with a neoadjuvant radiochemotherapy.
|
21956434 |
2012 |
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
The ERCC1 19007 C (rs11615) allele had null effects on overall risk of cancer; but in the stratified analyses, we observed an elevated association in Asian populations with homozygote variants and hospital-based controls.
|
22002622 |
2012 |
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
The ERCC1 19007 C (rs11615) allele had null effects on overall risk of cancer; but in the stratified analyses, we observed an elevated association in Asian populations with homozygote variants and hospital-based controls.
|
22002622 |
2012 |
|
Glioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
To examine the associations of two polymorphisms in excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1) gene, C8092A (rs3212986) and T19007C (rs11615), with the risk of adult glioma, we performed a hospital-based case-control study with 257 new cases of glioma and 278 controls in Wenzhou, China.
|
22201261 |
2012 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
|
22335888 |
2012 |
|
Malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
|
22335888 |
2012 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
|
22335888 |
2012 |
|
Malignant neoplasm of breast
|
|
0.080 |
GeneticVariation
|
BEFREE |
The ERCC1 rs11615 variant A/A genotype was associated with increased breast cancer risk in codominant, dominant,</span> and recessive models, and XPF rs6498486 variant C/C genotype carriers have a significantly increased breast cancer risk in codominant, dominant, and recessive models.
|
23909490 |
2013 |
|
Breast Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The ERCC1 rs11615 variant A/A genotype was associated with increased breast cancer risk in codominant, dominant,</span> and recessive models, and XPF rs6498486 variant C/C genotype carriers have a significantly increased breast cancer risk in codominant, dominant, and recessive models.
|
23909490 |
2013 |
|
Xeroderma pigmentosum, group F
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ERCC1 rs11615 variant A/A genotype was associated </span>with increased breast cancer risk in codominant, dominant, and recessive models, and XPF rs6498486 variant C/C genotype carriers have a significantly increased breast cancer risk in codominant, dominant, and recessive models.
|
23909490 |
2013 |
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Five SNPs (rs25487, rs25489, rs1799782, rs13181, and rs11615) were genotyped in 118 cancer patients using the classical method PCR restriction fragment length polymorphism (RFLP) and the high-throughput, automated assay Biotrove OpenArray(®) NT Cycler, trying to explore the feasibility and reproducibility of the OpenArray system in the context of oncology.
|
24103542 |
2013 |