|
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
The results showed in this systematic review contribute to better understanding of the association between the Arg913Gln variation of SLC12A3 gene with the pathogenesis of diabetic nephropathy in individuals with T2DM and GS.
|
31660880 |
2019 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN-ESRD in Chinese T2DM patients undergoing hemodialysis.
|
28744814 |
2018 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
This is the first study to report a significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
|
27699784 |
2016 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
We found that SLC12A3 Arg913Gln polymorphism was associated with T2D (p = 0.028, OR = 0.772, 95% CI = 0.612-0.973) and DN (p = 0.038, OR = 0.547, 95% CI = 0.308-0.973) in the Malaysian cohort.
|
25401745 |
2014 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
Three SNPs (g.34372G>A [Arg913Gln], g.39143G>A, and g.41727C>T) were found to be associated with ESRD due to diabetic nephropathy.
|
16505253 |
2006 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
We have shown previously that the SLC12A3 +78G/A polymorphism in exon 23 (Arg913Gln) was a new candidate for conferring susceptibility to diabetic nephropathy.
|
15915338 |
2005 |
|
Diabetic Nephropathy
|
|
0.070 |
GeneticVariation
|
BEFREE |
The results implicated that substitution of Arg913 to Gln in the SLC12A3 gene might reduce the risk to develop diabetic nephropathy and suggested that the gene product might be a potential target for the prevention or treatment of this disease.
|
14578305 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review.
|
31660880 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Arg913Gln of SLC12A3 gene promotes development and progression of end-stage renal disease in Chinese type 2 diabetes mellitus.
|
28744814 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that SLC12A3 Arg913Gln polymorphism was associated with T2D (p = 0.028, OR = 0.772, 95% CI = 0.612-0.973) and DN (p = 0.038, OR = 0.547, 95% CI = 0.308-0.973) in the Malaysian cohort.
|
25401745 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Polymorphism of the solute carrier family 12 (sodium/chloride transporters) member 3, SLC12A3, gene at exon 23 (+78G/A: Arg913Gln) is associated with elevation of urinary albumin excretion in Japanese patients with type 2 diabetes: a 10-year longitudinal study.
|
15915338 |
2005 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis.
|
23079845 |
2012 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
There was no significant association between the SLC12A3 R904Q variant and the ClC-Kb-T481S variant and essential hypertension in either ethnic group.
|
21644212 |
2011 |
|
Essential Hypertension
|
|
0.030 |
GeneticVariation
|
BEFREE |
The roles of Thr418Ser polymorphism of the CLCNKB gene and Arg904Gln polymorphism in the TSC gene on essential hypertension need to be explored in other ethnic groups.
|
17997379 |
2008 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN-ESRD in Chinese T2DM patients undergoing hemodialysis.
|
28744814 |
2018 |
|
Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups (P = 0.029 and 0.016, respectively).
|
27699784 |
2016 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
No association or trend with hypertension was observed at Arg904Gln in Kazaks.
|
17997379 |
2008 |
|
Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subsequent analysis of additional genetic variations in this gene identified several SNPs that were significantly associated with nephropathy, especially one in exon 23 (+78 G to A: Arg913Gln, chi(2) = 18.5, P = 0.00002, odds ratio = 2.53 [95% CI 1.64-3.90]).
|
14578305 |
2003 |
|
Gitelman Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review.
|
31660880 |
2019 |
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN-ESRD in Chinese T2DM patients undergoing hemodialysis.
|
28744814 |
2018 |
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN-ESRD in Chinese T2DM patients undergoing hemodialysis.
|
28744814 |
2018 |