|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs11671784 G/A and rs895819 A/G polymorphisms inversely affect gastric cancer susceptibility and miR-27a expression in a Chinese population.
|
25399405 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs11671784 G/A and rs895819 A/G polymorphisms inversely affect gastric cancer susceptibility and miR-27a expression in a Chinese population.
|
25399405 |
2014 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In summary, our results indicate that the G/A polymorphism in miR-27a gene (rs11671784</span>) decreases miR-27a expression, reduces gastric cancer risk and plays a role in gastric tumorigenesis.
|
23246964 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
In summary, our results indicate that the G/A polymorphism in miR-27a gene (rs11671784</span>) decreases miR-27a expression, reduces gastric cancer risk and plays a role in gastric tumorigenesis.
|
23246964 |
2014 |
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
These analyses reported that the SNPs rs11671784 (<i>MIR27A</i>, G/A) and rs2910164 (<i>MIR146A</i>, C/G) were significantly associated with AMD risk.
|
30934838 |
2019 |
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identified a causative relationship between rs11671784 G/A variation, lowered miR-27a expression, increased RUNX-1 expression and following weakened chemo-sensitivity. rs11671784 G allele has significantly stronger effect over A allele in promoting chemo-sensitivity in bladder cancer. miR-27a mediates chemotherapy at least partially through reducing P-gp expression and increasing apoptosis.
|
25656571 |
2015 |
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identified a causative relationship between rs11671784 G/A variation, lowered miR-27a expression, increased RUNX-1 expression and following weakened chemo-sensitivity. rs11671784 G allele has significantly stronger effect over A allele in promoting chemo-sensitivity in bladder cancer. miR-27a mediates chemotherapy at least partially through reducing P-gp expression and increasing apoptosis.
|
25656571 |
2015 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identified a causative relationship between rs11671784 G/A variation, lowered miR-27a expression, increased RUNX-1 expression and following weakened chemo-sensitivity. rs11671784 G allele has significantly stronger effect over A allele in promoting chemo-sensitivity in bladder cancer. miR-27a mediates chemotherapy at least partially through reducing P-gp expression and increasing apoptosis.
|
25656571 |
2015 |
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, our results indicate that the G/A polymorphism in miR-27a gene (rs11</span>671784) decreases miR-27a expression, reduces gastric cancer risk and plays a role in gastric tumorigenesis.
|
23246964 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the patients, rs895819 G variants were moderately associated with lymphatic invasion and lymph node metastasis, while rs11671784 A variants were associated with significantly reduced risk of lymphatic invasion. qRT-PCR results demonstrated rs895819 polymorphism contributed to an aberrant process from pri-miR-27a to pre-miR-27a, but rs11671784 did not affect the transcription and post-transcription processes of the miR-27a gene.
|
25399405 |
2014 |