|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
We aimed to investigate the relationship of type 2 diabetes with a Gly972Arg (G972R) variant of the <i>IRS-1</i> gene and Gly1057Asp (G1057D) polymorphism of <i>IRS-2</i> gene in the population of Punjab, Pakistan.
|
31404179 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association.
|
25959789 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
These results strongly argue against a major role of the Gly1057Asp IRS-2 polymorphism in the pathogenesis of type 2 diabetes in Djerbian subjects.
|
19332049 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15127203 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
The effect of the Gly1057Asp mutation on type 2 diabetes and obesity was tested in a large cohort of Pima Indians (n = 998).
|
12765968 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy).
|
12519871 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes.
|
12213887 |
2002 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity.
|
27098445 |
2016 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found significant difference in the genotypic distribution of IRS-2 gene Gly1057Asp between the PCOS group and the control group (p = 0.004).
|
25310961 |
2014 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women.
|
21801267 |
2011 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study was undertaken to determine whether IRS-1 Gly972Arg and IRS-2 Gly1057Asp influence hormonal and metabolic characteristics in Greek patients with polycystic ovary syndrome (PCOS) and controls.
|
20210696 |
2010 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
These results suggest that the IRS-2 Gly(1057)Asp polymorphism influences blood glucose levels in nondiabetic white and African-American women with PCOS.
|
12213887 |
2002 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.
|
11522686 |
2001 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association.
|
25959789 |
2015 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The effect of the Gly1057Asp mutation on type 2 diabetes and obesity was tested in a large cohort of Pima Indians (n = 998).
|
12765968 |
2003 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The concurrence of Gly1057Asp polymorphism in IRS-2 with DM is correlated with occurrence of CAD.
|
23216712 |
2012 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population.
|
23216712 |
2012 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population.
|
23216712 |
2012 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The concurrence of Gly1057Asp polymorphism in IRS-2 with DM is correlated with occurrence of CAD.
|
23216712 |
2012 |
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.
|
19878940 |
2010 |
|
Impaired insulin secretion
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gly1057Asp polymorphism was not associated with insulin resistance or impaired insulin secretion in Finnish subjects with normal glucose tolerance (n = 295) or impaired glucose tolerance (n = 38).
|
11473060 |
2001 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gly1057Asp polymorphism was not associated with insulin resistance or impaired insulin secretion in Finnish subjects with normal glucose tolerance (n = 295) or impaired glucose tolerance (n = 38).
|
11473060 |
2001 |