rs11980379, IKZF1

N. diseases: 3
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
CUI: C0023485
Disease: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
0.700 GeneticVariation GWASCAT Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. 29296818 2017
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
CUI: C0023485
Disease: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
0.700 GeneticVariation GWASCAT Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. 23996088 2013
Precursor B-cell lymphoblastic leukemia
CUI: C1292769
Disease: Precursor B-cell lymphoblastic leukemia
0.010 GeneticVariation BEFREE The previously reported pediatric B-ALL GWAS variant, rs11980379 (<i>IKZF1</i>), replicated in B-ALL pediatric patients (OR<sub>meta</sub> = 2.3; 95% CI, 1.5, 3.7; <i>P</i><sub>meta</sub> = 1.0 × 10<sup>-9</sup>), with evidence of heterogeneity (<i>P</i> = .02) between males and females. 29296818 2017
Childhood Acute Lymphoblastic Leukemia
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
0.010 GeneticVariation BEFREE On the one hand, the rs11980379 C allele increased the risk of ALL (OR = 1.70, 95 % CI = 1.17-2.46, p = 0.0062) compared with T allele, while the rs11978267 A/G polymorphism was not associated with ALL risk. 26790447 2016