rs12075, CADM3-AS1;ACKR1

N. diseases: 22
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
White Blood Cell Count procedure
CUI: C0023508
Disease: White Blood Cell Count procedure
0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
White Blood Cell Count procedure
CUI: C0023508
Disease: White Blood Cell Count procedure
0.800 GeneticVariation GWASDB Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. 22037903 2012
White Blood Cell Count procedure
CUI: C0023508
Disease: White Blood Cell Count procedure
0.800 GeneticVariation GWASCAT Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. 22037903 2012
White Blood Cell Count procedure
CUI: C0023508
Disease: White Blood Cell Count procedure
0.800 GeneticVariation GWASDB Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). 21738479 2011
Blood Protein Measurement
CUI: C2985280
Disease: Blood Protein Measurement
0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
Interleukin 8 Measurement
CUI: C2697788
Disease: Interleukin 8 Measurement
0.700 GeneticVariation GWASCAT Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. 27989323 2017
Monocyte count procedure
CUI: C0200637
Disease: Monocyte count procedure
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Blood basophil count (lab test)
CUI: C0200641
Disease: Blood basophil count (lab test)
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Monocyte count result
CUI: C0750880
Disease: Monocyte count result
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.700 GeneticVariation GWASDB A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. 22291609 2012
Polysomnography
CUI: C0162701
Disease: Polysomnography
0.700 GeneticVariation GWASDB Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.030 GeneticVariation BEFREE In this study, we evaluate the association between the <i>DARC</i> rs12075 polymorphism and liver stiffness progression in HCV-infected patients. 30970632 2019
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.030 GeneticVariation BEFREE Our result indicates that atypical chemokine receptor 1 polymorphism (rs12075) does not affect susceptibility to hepatitis C virus. 28443566 2017
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.030 GeneticVariation BEFREE Although serum CCL2 levels were associated with early liver fibrosis, rs12075 itself was not associated with HCV infection or the severity of liver disease in any of the cohorts. 21156192 2011
Fibrosis, Liver
CUI: C0239946
Disease: Fibrosis, Liver
0.020 GeneticVariation BEFREE Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis. 30970632 2019
Secondary malignant neoplasm of lymph node
0.020 GeneticVariation BEFREE Our previous research clarified two functional nonsynonymous single nucleotide polymorphisms (SNPs): rs12075 in DARC and rs2228468 in CCBP2 were significantly correlated with lymph node metastasis. 30358125 2018
Secondary malignant neoplasm of lymph node
0.020 GeneticVariation BEFREE Two non-synonymous SNPs, rs12075 (G42D) in DARC and rs2228468 (S373Y) in CCBP2, were observed to be associated with LNM in univariate analysis and remained significant after adjustment for conventional clinical risk factors, with odds ratios (ORs) of 0.54 (95% confidence interval [CI], 0.37 to 0.79) and 0.78 (95% CI, 0.62 to 0.98), respectively. 24260134 2013
Secondary malignant neoplasm of lymph node
0.020 GeneticVariation BEFREE Two non-synonymous SNPs, rs12075 (G42D) in DARC and rs2228468 (S373Y) in CCBP2, were observed to be associated with LNM in univariate analysis and remained significant after adjustment for conventional clinical risk factors, with odds ratios (ORs) of 0.54 (95% confidence interval [CI], 0.37 to 0.79) and 0.78 (95% CI, 0.62 to 0.98), respectively. 24260134 2013
Fibrosis, Liver
CUI: C0239946
Disease: Fibrosis, Liver
0.020 GeneticVariation BEFREE We here tested the hypothesis that this genetic variant (rs12075 A/G) is a risk factor for liver fibrosis in HCV infection. 21156192 2011
Malaria
CUI: C0024530
Disease: Malaria
0.010 GeneticVariation BEFREE FYB carriage (deduced from DARC G125A) was not associated with the risk of malaria per se but it protected against severe falciparum malaria (P = 0.03), and hospitalization (P = 0.006) due to falciparum malaria. 31551092 2019
Pseudohyperkalemia Cardiff
CUI: C1861453
Disease: Pseudohyperkalemia Cardiff
0.010 GeneticVariation BEFREE We found an association between the <i>DARC</i> rs12075 single nucleotide polymorphism (SNP) and CHC progression. 30970632 2019
Liver Cirrhosis
CUI: C0023890
Disease: Liver Cirrhosis
0.010 GeneticVariation BEFREE Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis. 30970632 2019
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.010 GeneticVariation BEFREE Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis. 30970632 2019
Malaria, Falciparum
CUI: C0024535
Disease: Malaria, Falciparum
0.010 GeneticVariation BEFREE FYB carriage (deduced from DARC G125A) was not associated with the risk of malaria per se but it protected against severe falciparum malaria (P = 0.03), and hospitalization (P = 0.006) due to falciparum malaria. 31551092 2019
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.010 GeneticVariation BEFREE Impact of <i>DARC</i> rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study. 30970632 2019