Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Via MTHFR C677T polymorphism, the findings in the present study demonstrated that there exists evidence on causal link between Hcy concentration and the risk of hypertension.
|
31769183 |
2019 |
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled results showed that MTHFR C677T variant increased the risk of ischemic stroke (OR = 1.23, 95%CI 1.06-1.43, P = 0.0067 for CT + TT vs. CC; OR = 1.18, 95%CI 1.01-1.38, P = 0.0333 for CT vs. CC; OR = 1.41, 95%CI 1.14-1.75, P = 0.0016 for TT vs. CC; OR = 1.27, 95%CI 1.05-1.54, P = 0.0145 for TT vs. CC + CT; OR = 1.18, 95%CI 1.06-1.31, P = 0.0023 for T-allele vs. C-allele).
|
31775641 |
2019 |
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL.
|
30545275 |
2019 |
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been associated with many pathologies, including cancer.
|
31170928 |
2019 |
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, it has been shown in patients with breast cancer a risk of presenting with an aggressive biophenotype about twice or three times higher in the presence of the C677T and A1298C polymorphisms, respectively.
|
31523170 |
2019 |
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
|
29222906 |
2019 |
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The laboratory tests revealed high D-dimers, and positive IgG anti-cardiolipin and anti-beta2 glycoproteins I antibodies, whereas the genetic profile for thrombophilia revealed heterozygote mutation in MTHFR C677T and A1298C genes.
|
31725629 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations.
|
31663297 |
2019 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5,10-MTHFR 677C>T and RFC1 80G>A polymorphisms are associated with an increased risk of susceptibility to pediatric ALL.
|
31499477 |
2019 |
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The distribution of genotype frequency at C677T polymorphism site was significantly different between the CHD group (including ventricular septal defect, atrial septal defect, tetralogy of fallot, double outlet right ventricle, patent ductus arteriosus) (child and mother) and healthy control group (child and mother).
|
30334422 |
2019 |
Migraine Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expert opinion: Determination of MTHFR C677T polymorphisms as well as measurement of homocysteine concentrations may be useful to migraine patients, particularly those suffering from migraine with aura.
|
30451038 |
2019 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL.
|
30545275 |
2019 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no difference in the distribution of the <i>MTHFR</i> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW.
|
31496910 |
2019 |
Malignant tumor of cervix
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism was not associated with cervical cancer and HPV infection.
|
31170928 |
2019 |
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we first adopted methylenetetrahytrofolate reductase (MTHFR) gene C677T polymorphism as an instrument to infer the possible causal relevance between circulating homocysteine and DKD risk in a Chinese population and next attempted to build a risk prediction model for DKD.
|
30729677 |
2019 |
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
Miscarriage
|
|
0.100 |
GeneticVariation
|
BEFREE |
Investigation of the association between C677T polymorphism of the MTHFR gene and plasma homocysteine level in recurrent fetal miscarriage.
|
31172624 |
2019 |
Down Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T, but not A1298C, was associated with neural tube defects (OR, 1.24; 95% CI, 1.08-1.42) and Down syndrome (OR, 1.65; 95% CI, 1.39-1.95).
|
30474229 |
2019 |
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians.
|
30813130 |
2019 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present updated meta-analysis demonstrated that the MTHFR C677T polymorphism was significantly associated with susceptibility to lung cancer in Chinese people.
|
31192962 |
2019 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While C677T is known to play major roles in the risk of adult schizophrenia, our finding for the first time suggests an age-specific association between MTHFR polymorphisms and schizophrenia.
|
31302825 |
2019 |