NOONAN SYNDROME 7
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Noonan syndrome: clinical features, diagnosis, and management guidelines.
|
20876176 |
2010 |
NOONAN SYNDROME 7
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
|
19206169 |
2009 |
NOONAN SYNDROME 7
|
|
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
|
23833300 |
2013 |
Carcinoma of lung
|
|
0.700 |
CausalMutation
|
CLINVAR |
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
|
23833300 |
2013 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
|
23715574 |
2013 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.
|
22805292 |
2012 |
Non-Small Cell Lung Carcinoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
|
22892241 |
2012 |
Cardio-facio-cutaneous syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
|
22892241 |
2012 |
Carcinoma of lung
|
|
0.700 |
CausalMutation
|
CLINVAR |
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.
|
22798288 |
2012 |
Noonan Syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
|
22892241 |
2012 |
Carcinoma of lung
|
|
0.700 |
CausalMutation
|
CLINVAR |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.
|
22798288 |
2012 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
Cardio-facio-cutaneous syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.
|
23093928 |
2012 |
Non-Small Cell Lung Carcinoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.
|
23093928 |
2012 |
Noonan Syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.
|
23093928 |
2012 |
Carcinoma of lung
|
|
0.700 |
CausalMutation
|
CLINVAR |
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.
|
21483012 |
2011 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.
|
21483012 |
2011 |
melanoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
|
19238210 |
2009 |
Non-Small Cell Lung Carcinoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
|
19206169 |
2009 |
Cardio-facio-cutaneous syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
|
19206169 |
2009 |
Carcinoma of lung
|
|
0.700 |
CausalMutation
|
CLINVAR |
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
|
19238210 |
2009 |
Noonan Syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
|
19206169 |
2009 |