|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Corrigendum: Afatinib for Advanced Non-small Cell Lung Cancer in a Case With an Uncommon Epidermal Growth Factor Receptor Mutation (G719A) Identified in the Cerebrospinal Fluid.
|
31641649 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Moreover, TAS-121 displayed antitumor activity in SW48 (<i>EGFR</i> G719S) and NCI-H1975 (<i>EGFR</i> L858R/T790M) xenograft models, and achieved an objective response in patients with NSCLC with <i>EGFR</i> mutations including G719A mutation.
|
30872380 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Notably, NGS of CSF was superior to genetic testing of peripheral blood at identifying an uncommon EGFR mutation (G719A) in a patient with NSCLC and leptomeningeal metastases.
|
31396478 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Low frequency KRAS active (G12R) and EGFR kinase domain mutations (G719A) were identified in one NSCLC patient.
|
24200637 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib.
|
23102728 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
GeneticVariation
|
CLINVAR |
Erlotinib response in an NSCLC patient with a novel compound G719D+L861R mutation in EGFR.
|
23945392 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors.
|
23242437 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
|
22753918 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
"Effectiveness of tyrosine kinase inhibitors on ""uncommon"" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer."
|
21531810 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer.
|
20479403 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer.
|
19922469 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
|
18458038 |
2008 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence.
|
15738541 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas.
|
16115929 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer.
|
16011858 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib.
|
15710947 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
|
15118125 |
2004 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
|
15118073 |
2004 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
"EGF receptor gene mutations are common in lung cancers from ""never smokers"" and are associated with sensitivity of tumors to gefitinib and erlotinib."
|
15329413 |
2004 |
|
Non-Small Cell Lung Carcinoma
|
|
0.740 |
CausalMutation
|
CLINVAR |
Effects of marine oil-enriched diets on guinea pig megakaryocyte and platelet lipids: effects on thromboxane synthesis and platelet function.
|
2302402 |
1990 |
|
Glioblastoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Glioblastoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |