rs1260326, GCKR

N. diseases: 63
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation BEFREE Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively. 26578543 2016
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation GWASDB Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. 23505323 2013
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation BEFREE The rs1260326 was associated with elevated triglycerides (Caucasians P = 0.00014; African Americans P = 0.00417), large very low-density lipoprotein (VLDL) (Caucasians P = 0.001; African Americans, P = 0.03), and with fatty liver (Caucasians P = 0.034; African Americans P = 0.00002; and Hispanics P = 0.016). 22105854 2012
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation GWASDB Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation GWASCAT Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2017
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2017
Glomerular filtration rate finding
CUI: C1561549
Disease: Glomerular filtration rate finding
0.800 GeneticVariation GWASCAT Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. 27588450 2017
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
Platelet Count measurement
CUI: C0032181
Disease: Platelet Count measurement
0.800 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2017
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2017
Uric acid measurement (procedure)
CUI: C0202239
Disease: Uric acid measurement (procedure)
0.800 GeneticVariation GWASCAT Modulation of genetic associations with serum urate levels by body-mass-index in humans. 25811787 2016
Protein measurement
CUI: C0202202
Disease: Protein measurement
0.800 GeneticVariation GWASCAT Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. 27005778 2016
Glomerular filtration rate finding
CUI: C1561549
Disease: Glomerular filtration rate finding
0.800 GeneticVariation GWASCAT Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 26831199 2016
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2014
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2014
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2014
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2014
Uric acid measurement (procedure)
CUI: C0202239
Disease: Uric acid measurement (procedure)
0.800 GeneticVariation GWASCAT Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
Serum albumin measurement
CUI: C0523465
Disease: Serum albumin measurement
0.800 GeneticVariation GWASDB Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 23022100 2013
Serum albumin measurement
CUI: C0523465
Disease: Serum albumin measurement
0.800 GeneticVariation GWASCAT Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 23022100 2013
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASDB A genome wide association study identifies common variants associated with lipid levels in the Chinese population. 24386095 2013
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASDB Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. 23236364 2013