|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that rs12608932(C) is associated with increased ALS susceptibility, especially in Caucasian and European subjects, and that the CC genotype of rs12608932 is associated with reduced ALS patient survival.
|
31201598 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our findings demonstrate converging evidence that rs12608932 may modify frontotemporal disease in sporadic ALS and suggest that rs12608932 may function as a prognostic indicator and could be used to define patient endophenotypes in clinical trials.
|
30368160 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
|
27455348 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
136 sporadic ALS (sALS) patients and 487 healthy controls were genotyped for the UNC13A rs12608932 variant.
|
26162714 |
2015 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASDB |
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
|
24234648 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Recently, four single nucleotide polymorphisms (SNPs), including rs2814707 in the 9p21, rs12608932 in the UNC13A gene, rs13048019 in the TIMA1 gene, and rs2228576 in the SCNN1A gene have been reported to be associated with the risk for developing amyotrophic lateral sclerosis (ALS) in Caucasian population.
|
24493373 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASCAT |
C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis.
|
24931836 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Overall, minor allele carrier status of rs12608932 was strongly associated with an approximate 1-year reduction of survival in ALS patients, making it a significant determinant of phenotype variation.
|
22921269 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
In both cohorts, the minor allele of rs12608932 in UNC13A was not only associated with susceptibility but also with shorter survival of ALS patients.
|
22118904 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
BEFREE |
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians.
|
21295378 |
2011 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASDB |
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
|
20801717 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
Amyotrophic Lateral Sclerosis
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.720 |
GeneticVariation
|
BEFREE |
A large genome-wide screen in patients with sporadic amyotrophic lateral sclerosis (ALS) showed that the common variant rs12608932 in gene UNC13A was associated with disease susceptibility.
|
22118904 |
2012 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.720 |
GeneticVariation
|
BEFREE |
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians.
|
21295378 |
2011 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |