High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations.
|
26582766 |
2016 |
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry: A Substudy of the Paris Prospective Study 3.
|
26160806 |
2015 |
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Here we apply an EMR-based phenotyping approach, within the context of routine care, to replicate several known associations between HDL-C and previously characterized genetic variants: CETP (rs3764261, p = 1.22e-25), LIPC (rs11855284, p = 3.92e-14), LPL (rs12678919, p = 1.99e-7), and the APOA1/C3/A4/A5 locus (rs964184, p = 1.06e-5), all adjusted for age, gender, body mass index (BMI), and smoking status.
|
21589926 |
2011 |
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
High density lipoprotein measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
|
24386095 |
2013 |
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
22916037 |
2012 |
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.
|
21589926 |
2011 |
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
Coronary heart disease
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
Pseudocholinesterase Measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
|
21943158 |
2011 |
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
19060906 |
2009 |
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Individuals carrying the lipoprotein lipase (LPL) rs12678919 polymorphism (A → G) had no significant change in the risk of developing AMD (OR = 1.01, CI: 0.92-1.10, P = 0.17).
|
26503844 |
2015 |
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
After multivariate adjustment for age, sex, educational level, smoking, BMI, lipid-lowering medication use, cardiovascular disease and diabetes, and for all relevant genetic polymorphisms (ApoE2, ApoE4, CFH Y402H, ARMS2 A69S, LIPC rs10468017, LIPC rs493258, LPL rs12678919, ABCA1 rs1883025 and CETP rs3764261), higher HDL was significantly associated with an increased risk of early (OR = 2.45, 95%CI: 1.54-3.90; P = 0.0002) and any AMD (OR = 2.29, 95%CI: 1.46-3.59; P = 0.0003).
|
24608419 |
2014 |
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration.
|
30399423 |
2019 |
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Rs10468017 in LIPC, rs12678919 near LPL and rs1883025 in ABCA1 were not found to be associated with advanced AMD (all p > 0.05).
|
24498989 |
2015 |
Polypoidal choroidal vasculopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
LIPC rs493258 and LPL rs12678919 did not show significant associations with the development of PCV (P > 0.05).
|
23950155 |
2013 |
Polypoidal choroidal vasculopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found no association between PCV and LPL rs12678919, LIPC rs10468017 or CETP rs173539.
|
26624898 |
2015 |