rs12696304, None

N. diseases: 10
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Systolic Pressure
CUI: C0871470
Disease: Systolic Pressure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Malignant melanoma of skin of lower limb
CUI: C0153536
Disease: Malignant melanoma of skin of lower limb
0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
Malignant melanoma of skin of upper limb
CUI: C0153535
Disease: Malignant melanoma of skin of upper limb
0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
Cutaneous Melanoma
CUI: C0151779
Disease: Cutaneous Melanoma
0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
Cutaneous Melanoma
CUI: C0151779
Disease: Cutaneous Melanoma
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. 26237428 2015
Malignant melanoma of skin of upper limb
CUI: C0153535
Disease: Malignant melanoma of skin of upper limb
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. 26237428 2015
Malignant melanoma of skin of lower limb
CUI: C0153536
Disease: Malignant melanoma of skin of lower limb
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. 26237428 2015
Lung Diseases, Interstitial
CUI: C0206062
Disease: Lung Diseases, Interstitial
0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
Tooth Attrition
CUI: C0004277
Disease: Tooth Attrition
0.020 GeneticVariation BEFREE Our findings suggest that the TERC rs12696304 SNP interacts with MUFA improving inflammation status and telomere attrition related with CHD. 27707805 2018
Tooth Attrition
CUI: C0004277
Disease: Tooth Attrition
0.020 GeneticVariation BEFREE Each copy of the major allele of rs12696304 and rs16847897 was associated with a shorter mean telomere length of 0.024 and 0.031 T/S respectively, which is equivalent to about 3 and 4 years of average age-related telomere attrition. 21304559 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.010 GeneticVariation BEFREE Our findings suggest that the TERC rs12696304 SNP interacts with MUFA improving inflammation status and telomere attrition related with CHD. 27707805 2018
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.010 GeneticVariation BEFREE The fact that the MNS16 L allele has been reported to lower TERT expression, and that the TERC alleles G, T, C (rs12696304, rs3772190, rs16847897 in this order have been repeatedly found associated with shorter LTL, seems to corroborate the hypothesis of a role of telomere length and telomerase in AD susceptibility. 28039025 2017
Acute Coronary Syndrome
CUI: C0948089
Disease: Acute Coronary Syndrome
0.010 GeneticVariation BEFREE In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls). 26765095 2016
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE [CC] genotype of rs16847897 and [GG] genotype of rs12696304 together increased the risk of T2DM significantly [OR = 1.7, p = 0.004]. 26720590 2015