Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
Stratified analysis was applied for INHA 769G>A by ethnicity; a significant association with POF was only found in the Asian subgroup (allelic frequency: OR 8.89, 95% CI 2.1-5.52; p=0.004).
|
25445105 |
2014 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
Stratified analysis was applied for INHA 769G>A by ethnicity; a significant association with POF was only found in the Asian subgroup (allelic frequency: OR 8.89, 95% CI 2.1-5.52; p=0.004).
|
25445105 |
2014 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis.
|
21785376 |
2011 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis.
|
21785376 |
2011 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
Although the reduction of inhibin B bioactivity by the INHA G769A mutation is clearly not the only cause, evidence suggests that this change may serve as a susceptibility factor, increasing the likelihood of POF.
|
19752047 |
2010 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
Although the reduction of inhibin B bioactivity by the INHA G769A mutation is clearly not the only cause, evidence suggests that this change may serve as a susceptibility factor, increasing the likelihood of POF.
|
19752047 |
2010 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
The meta-analysis showed significant heterogeneity among the studies (P(Q) = 0.01, I(2) = 74%) and lack of evidence that carriers of the G769A variant confer risk of POF: OR = 1.38 (0.48-3.94).
|
19542176 |
2009 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
The meta-analysis showed significant heterogeneity among the studies (P(Q) = 0.01, I(2) = 74%) and lack of evidence that carriers of the G769A variant confer risk of POF: OR = 1.38 (0.48-3.94).
|
19542176 |
2009 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
This study supports the hypothesis that the INHA 769G>A variant may increase susceptibility to POF with impaired inhibin B bioactivity and provides insight into the complex aetiology of POF.
|
17933751 |
2007 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
This study supports the hypothesis that the INHA 769G>A variant may increase susceptibility to POF with impaired inhibin B bioactivity and provides insight into the complex aetiology of POF.
|
17933751 |
2007 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results indicate that -16C>T and 769G>A variants in INHalpha gene may not be associated to POF disease.
|
16396934 |
2006 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results indicate that -16C>T and 769G>A variants in INHalpha gene may not be associated to POF disease.
|
16396934 |
2006 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
G769A variation of INHalpha is rare in Korea women with POF.
|
15227735 |
2004 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
G769A variation of INHalpha is rare in Korea women with POF.
|
15227735 |
2004 |
Premature Menopause
|
|
0.080 |
GeneticVariation
|
BEFREE |
The analysis of pedigrees showing the inheritance of the 769G-->A mutation and POF strengthens the concept of the disease heterogeneity, since the POF phenotype was not always associated with the mutation.
|
12093833 |
2002 |
Ovarian Failure, Premature
|
|
0.080 |
GeneticVariation
|
BEFREE |
The analysis of pedigrees showing the inheritance of the 769G-->A mutation and POF strengthens the concept of the disease heterogeneity, since the POF phenotype was not always associated with the mutation.
|
12093833 |
2002 |