|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings are the first to suggest an association between rs12807809 and abnormal Papez circuit function in patients with SZ.
|
30953482 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed an association of rs12807809 with SCZ in this study population.
|
28389239 |
2017 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A meta-analysis of rs12807809 was also conducted to verify its association with schizophrenia in Han Chinese population.
|
26828755 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion rs12807809 polymorphism may not contribute to the risk of schizophrenia but influence the clinical symptoms of schizophrenia in the Han population.
|
25739323 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
After applying Bonferroni correction for 13 genotype measures and setting P-values for significance (P<0.0039; 0.05/13), three effects remained significant: the rs12807809-rs12278912 diplotype-diagnosis interactions on performance intelligence quotient (CG/CG: P=3.9 × 10(-13); TA/TA: P=1.1 × 10(-7)) and TA/TA diplotype on performance intelligence quotient in patients with schizophrenia (P=8.2 × 10(-8)) remained significant.
|
23903071 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.
|
24386483 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two schizophrenia-associated NRGN SNPs (rs12807809 and rs12541) were tested for association with working memory-elicited dorsolateral prefrontal cortex (DLPFC) activity and surface-wide cortical thickness.
|
24098564 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variation in rs12807809 in the NRGN gene has recently been confirmed to be associated with schizophrenia in a meta-analysis of genome-wide association studies: the T-allele was found to be genome-wide significantly associated with schizophrenia.
|
21799211 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function.
|
22856365 |
2012 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study provides further evidence of the association of the NRGN gene with schizophrenia, and our results suggest that there is a link between the TG haplotype of rs12807809-rs12278912, decreased expression of NRGN and risk of developing schizophrenia.
|
22461181 |
2012 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In order to find the causal variants of NRGN gene in schizophrenia, we searched for genetic variants in the promoter region and all the exons (including both UTR ends and rs12807809) using direct sequencing in a sample of patients with schizophrenia (n=346) and non-psychotic controls (n=345), both being Han Chinese from Taiwan, and conducted an association and functional study.
|
22306195 |
2012 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotype effects of rs12807809 were investigated on gray matter (GM) and white matter (WM) volumes using magnetic resonance imaging (MRI) with a voxel-based morphometry (VBM) technique in a sample of 99 Japanese patients with schizophrenia and 263 healthy controls.
|
22253779 |
2012 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
|
21791550 |
2011 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We sought to determine if (a) NRGN contains common exonic variants or variants affecting expression (eQTLs) that could account for the association with rs12807809 and (b) there exist rare non-synonymous highly penetrant variants that could potentially confer high risk of schizophrenia.
|
21538840 |
2011 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results confirm that common risk factors in the major histocompatibility complex region and TCF4 gene are associated with schizophrenia in Han Chinese, but our results fail to show an association with SNP rs12807809 in the NRGN gene.
|
20673877 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants conferring risk of schizophrenia.
|
19571808 |
2009 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Common variants conferring risk of schizophrenia.
|
19571808 |
2009 |
|
Psychotic Disorders
|
|
0.720 |
GeneticVariation
|
BEFREE |
Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population.
|
28389239 |
2017 |
|
Psychotic Disorders
|
|
0.720 |
GeneticVariation
|
BEFREE |
Despite the association between NRGN and psychoses we have found, we failed to validate the positive variant rs12807809, which was reported in the Caucasian genome-wide association study both in our single site association test and the meta-analysis.
|
26828755 |
2016 |
|
Psychotic Disorders
|
|
0.720 |
GeneticVariation
|
GWASDB |
Common variant at 16p11.2 conferring risk of psychosis.
|
23164818 |
2014 |
|
Nonorganic psychosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population.
|
28389239 |
2017 |
|
Hallucinations
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further Genotype-Phenotype correlation revealed a moderate association of rs12807809 with flat affect (p=0.039) and Hallucinations (p=0.012).
|
28389239 |
2017 |