|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms near MC4R and GNPDA2 genes were significantly associated with type 2 diabetes before adjusting for body mass index and waist circumference (OR (95% CI) = 1.14 (1.06, 1.22) for the A allele of rs12970134, P = 4.75×10(-4); OR (95% CI) = 1.10 (1.03, 1.17) for the G allele of rs10938397, P = 4.54×10(-3)).
|
25093408 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
Meta-analysis of rs12970134 in >12 000 Indian adults corroborated its association with adiposity (P≤2.2 × 10(-9)), homeostasis model assessment-estimated insulin resistance (P=4.0 × 10(-5)) and type 2 diabetes (P=0.003) with only moderate heterogeneity, suggesting similar effect on adult Indians residing in different geographical regions.
|
23151679 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India.
|
19680233 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.840 |
GeneticVariation
|
BEFREE |
The frequency of the minor risk alleles of rs17782313 and rs12970134 was higher among patients with type 2 diabetes than among glucose-tolerant individuals (OR 1.08, P = 0.08 and 1.08, P = 0.06, respectively); however, these borderline associations were abolished after adjustment for BMI.
|
19073769 |
2009 |
|
Body Weight
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
|
19079260 |
2009 |
|
Body Weight
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
|
19079260 |
2009 |
|
Body mass index procedure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Finding of body mass index
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Body mass index procedure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
|
19079260 |
2009 |
|
Finding of body mass index
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
|
19079260 |
2009 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
|
19079260 |
2009 |
|
Waist Circumference
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference.
|
18454146 |
2008 |
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
|
18454146 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified the effect of MC4R rs12970134 on overweight/obesity and BMI, and we also found physical activity and sedentary behaviors modified the association between the rs12970134 and BMI in Chinese children and adolescents.
|
28081251 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The family-based association analysis showed that there was a significant association between rs12970134 and obesity (Z = 2.449, P = 0.014).
|
28520814 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not confirm the explicit effect of rs12970134 on obesity.
|
26680479 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |