|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1333040 (dominant model: P < 0.0001; recessive model: P < 0.0001; allele model: P < 0.0001), rs1333049 (dominant model: P = 0.02; allele model: P = 0.02) and rs2383207 (additive model: P = 0.004; allele model: P = 0.03) polymorphisms were significantly associated with the likelihood of CAD.
|
30387168 |
2019 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.
|
25333979 |
2015 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population.
|
20691078 |
2010 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients.
|
21362310 |
2011 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined whether genotype at the lead CAD-associated single nucleotide polymorphism (rs1333049) in 9p21 was associated with: 1) basal levels of IFN-I in plasma from 148 healthy male subjects; 2) induction of IFN-I by Toll-like receptor stimulants in peripheral blood mononuclear cells of 60 healthy volunteers assessed by enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21 CAD risk region in reporter assays.
|
23933542 |
2013 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |