|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In all, 950 patients with early onset CAD (age 56.1 +/- 9.6 years) and an independent sample of 764 patients with late onset CAD (age 70.0 +/- 8.0 years) were enrolled from the cardiac catheterization laboratories at the University of Ottawa Heart Institute from April 15, 2006, to August 15, 2008, and genotyped for the single nucleotide polymorphism rs1333049 9p21 risk variant.Angiographers were blinded to genotype.
|
20670758 |
2010 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population.
|
20691078 |
2010 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
|
19548844 |
2009 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study.
|
19171343 |
2009 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data from two populations show that variant rs1333049 is significantly associated with angiographically characterized CAD.
|
19135198 |
2009 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The meta-analysis of the rs1333049 SNP in 12,0</span>04 cases and 28,949 controls increased the overall level of evidence for association with CAD to P=6.04x10(-10) (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29).
|
18362232 |
2008 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |