|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
|
26066377 |
2015 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our meta-analysis results indicate that the IRGM rs13361189 polymorphism contributes to the susceptibility to CD.
|
25526194 |
2014 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
The analysis showed modest significant association for the rs13361189, rs4958847 and rs10065172 variants in Crohn's disease (CD): the risk estimates for the allele contrast were OR=1.306 (1.200-1.420), p=5.2 × 10(-10), OR=1.182 (1.082-1.290), p=0.0002, and OR=1.248 (1.057-1.473), p=0.009 respectively (still significant when the p value was Bonferroni adjusted to 0.017).
|
24232856 |
2013 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P=1.07 x 10(-19), pooled OR=1.34; rs4958847 A allele P=2.78 x 10(-17), pooled OR=1.31) and UC (rs13361189 P=0.0069, pooled OR=1.16; rs4958847 P=0.014, pooled OR=1.13).
|
19491842 |
2009 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
NCF4 and IRGM were significantly associated with ileal CD (P-value(rs4821544)=0.0090, odds ratio (OR)=1.425, 95% confidence interval (CI): 1.092-1.859; P-value(rs13361189)=0.0017, OR=1.942, 95% CI: 1.274-2.959; P-value(rs4958847)=0.0022, OR=1.767, 95% CI: 1.224-2.558), but not with other forms of inflammatory bowel disease (IBD).
|
18580884 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
Crohn Disease
|
|
0.850 |
GeneticVariation
|
GWASDB |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We examined the relationship between IRGM rs13361189 variants and NAFLD in a community-based cohort of adults.
|
30597691 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The relationship between VAT and NAFLD was modified by IRGM variants rs4958847 and rs13361189 (Pinteraction = 0.005 and Pinteraction < 0.001, respectively).
|
29788077 |
2018 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conversely, there was no association of rs13361189 or rs4958847 variant with risk of ulcerative colitis (UC).
|
24232856 |
2013 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, our meta-analysis data showed that IRGM rs13361189 and rs4958847 polymorphisms were associated with CD (rs13361189 C allele P=1.07 x 10(-19), pooled OR=1.34; rs4958847 A allele P=2.78 x 10(-17), pooled OR=1.31) and UC (rs13361189 P=0.0069, pooled OR=1.16; rs4958847 P=0.014, pooled OR=1.13).
|
19491842 |
2009 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our community-based, longitudinal cohort of Caucasian adults, variants in the autophagy-governing IRGM gene at the rs13361189 locus were not associated with increased prevalent or incident HS.
|
30597691 |
2019 |
|
Fatty Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
In our community-based, longitudinal cohort of Caucasian adults, variants in the autophagy-governing IRGM gene at the rs13361189 locus were not associated with increased prevalent or incident HS.
|
30597691 |
2019 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
T allele of rs10065172, A allele of rs4958847, and C allele of rs13361189 were all higher in Graves' disease patients than controls, and the ORs were OR = 1.207 (<i>P</i> = 0.022), OR = 1.207 (<i>P</i> = 0.027), and OR = 1.200 (<i>P</i> = 0.027), respectively.
|
29992164 |
2018 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interferon-gamma release levels were tested by T-SPOT. rs10065172 (P = 0.024, OR 0.67 (95% CI 0.48-0.95)), rs10051924 (P = 0.01, OR 0.64 (95% CI 0.46-0.90)), and rs13361189 (P = 0.055, OR 0.72 (95% CI 0.51-1.01)) were associated with a protective role against latent TB progression.
|
26980495 |
2016 |
|
Ileal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs13361189 was also found to increase the risk of Crohn's disease clinical sub-phenotype (fibrostricturing behaviour, ileal disease, perianal disease, intestinal resection).
|
26066377 |
2015 |
|
Intestinal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs13361189 was also found to increase the risk of Crohn's disease clinical sub-phenotype (fibrostricturing behaviour, ileal disease, perianal disease, intestinal resection).
|
26066377 |
2015 |
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the current study, we investigated two IRGM genetic polymorphisms, rs10065172C/T and rs13361189T/C, in glioma and their effects on cytokine expression.
|
24859836 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer.
|
22713085 |
2012 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer.
|
22713085 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
NCF4 and IRGM were significantly associated with ileal CD (P-value(rs4821544)=0.0090, odds ratio (OR)=1.425, 95% confidence interval (CI): 1.092-1.859; P-value(rs13361189)=0.0017, OR=1.942, 95% CI: 1.274-2.959; P-value(rs4958847)=0.0022, OR=1.767, 95% CI: 1.224-2.558), but not with other forms of inflammatory bowel disease (IBD).
|
18580884 |
2008 |