|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
The T-allele of the SNP rs12255372 of TCF7L2 (OR = 2.70, 95% CI = 1.12-6.49, P = 0.027) and the A-allele of PDX-1 D76N (OR = 3.93, 95% CI = 1.60-7.68, P = 0.002) were significantly associated with an increased risk of T2DM.
|
26058934 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
So far, this is the largest association study regarding the effect of D76N IPF1 on T2D.
|
17592437 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
We genotyped U.S. Caucasians with (n = 217) and without (n = 176) Type 2 diabetes to determine if three previously identified variants (Cys18Arg, Asp76Asn, Arg197His) in the IPF-1 gene play a role in the development of Type 2 diabetes.
|
11914043 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
The D76N variant was found in one MODY3 family (S315fsinsA of HNF1alpha) and also in two families with late-onset Type II diabetes.
|
11270685 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
GeneticVariation
|
BEFREE |
In the patients with late-onset type 2 diabetes we identified a noncoding G insertion/deletion polymorphism at nucleotide -108, a silent G54G, and a rare missense D76N variant.
|
10720084 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.760 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Maturity onset diabetes mellitus in young
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |
|
Diabetes
|
|
0.040 |
GeneticVariation
|
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |
|
Diabetes
|
|
0.040 |
GeneticVariation
|
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
We did not detect the D76N variant, which was the most frequent variant in subjects with a strong family history of diabetes, in patients or controls.
|
11022198 |
2000 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
Neither the D76N nor the A140T segregated with diabetes, and their transcriptional activation of the human insulin promoter expressed in vitro was indistinguishable from that of the wild type (115 +/- 21% and 84 +/- 12% vs. 100%).
|
10720084 |
2000 |
|
Diabetes
|
|
0.040 |
GeneticVariation
|
BEFREE |
We did not detect the D76N variant, which was the most frequent variant in subjects with a strong family history of diabetes, in patients or controls.
|
11022198 |
2000 |
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |
|
Diabetes
|
|
0.040 |
GeneticVariation
|
BEFREE |
The lower penetrance D76N and Q59L mutations were more prevalent and were associated with a relative risk of 12.6 for diabetes and with decreased glucose-stimulated insulin-secretion in nondiabetic subjects.
|
10545531 |
1999 |