rs1452787, TCF4

N. diseases: 5
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cholangitis, Sclerosing
CUI: C0008313
Disease: Cholangitis, Sclerosing
0.800 GeneticVariation GWASCAT Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. 22821403 2013
Cholangitis, Sclerosing
CUI: C0008313
Disease: Cholangitis, Sclerosing
0.800 GeneticVariation GWASDB Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. 22821403 2013
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.700 GeneticVariation GWASCAT Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. 29662059 2018
Fuchs Endothelial Dystrophy
CUI: C0016781
Disease: Fuchs Endothelial Dystrophy
0.010 GeneticVariation BEFREE SNPs were detected for TCF4 (rs613872, rs2123392, rs17089887, rs1452787, and rs1348047), but only rs613872 showed a significant association with FECD (P = 9.93 × 10). 30973406 2019
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.010 GeneticVariation BEFREE Further interaction and stratification analysis suggested that rs1452787 was notably correlated with increased SCZ risk in males (OR = 2.77, 95%CI = 1.43-5.35, P = 0.002). 27103199 2016
Primary sclerosing cholangitis
CUI: C0566602
Disease: Primary sclerosing cholangitis
0.010 GeneticVariation BEFREE We discovered novel genome-wide significant associations with PSC at 2q37 [rs3749171 at G-protein-coupled receptor 35 (GPR35); P = 3.0 × 10(-9) in the overall study population, combined odds ratio [OR] and 95% confidence interval [CI] of 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 × 10(-8) , OR (95% CI) = 0.75 (0.68-0.83)]. 22821403 2013