rs148704956, IL17A

N. diseases: 19
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE The IL-17A G197A variant may be utilized as a genetic screening marker in assessing CRC risk, and its expression can be used as a biomarker for early detection of CRC in the Saudi population. 30233234 2018
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.040 GeneticVariation BEFREE The current meta-analysis suggests that IL-17A G197A polymorphism might enhance gastric cancer risk. 29440917 2018
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE The current meta-analysis suggests that IL-17A G197A polymorphism might enhance gastric cancer risk. 29440917 2018
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer. 29970680 2018
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE We also observed a significant association between the AG genotype of IL-17A G197A SNP with increased risk of colorectal cancer as compared to AA genotype (P=0.001). 25680555 2015
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE Stratified analysis by cancer type revealed that the IL-17A G197A polymorphism may increase the risk of gastric cancer. 24965422 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE Significant association was observed between IL-17A G</span>197A polymorphism and gastric cancer risk, particularly among Asians. 25008567 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.040 GeneticVariation BEFREE Stratified analysis by cancer type revealed that the IL-17A G197A polymorphism may increase the risk of gastric cancer. 24965422 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.040 GeneticVariation BEFREE Significant association was observed between IL-17A G</span>197A polymorphism and gastric cancer risk, particularly among Asians. 25008567 2014
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE We have noted a significant association of IL17A G197A polymorphism not only with tumor localization (p = 0.003) but also with tumor differentiation (p = 0.0005) in CRC patients. 24699997 2014
Malignant neoplasm of stomach
CUI: C0024623
Disease: Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE We conducted a case-control study including 1,010 gastric cancer patients and 800 healthy controls to assess the association between IL-17A G197A and IL-17F A7488G polymorphisms and risk of gastric cancer. 19904747 2010
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.040 GeneticVariation BEFREE We conducted a case-control study including 1,010 gastric cancer patients and 800 healthy controls to assess the association between IL-17A G197A and IL-17F A7488G polymorphisms and risk of gastric cancer. 19904747 2010
Malignant neoplasm of colon and/or rectum
0.030 GeneticVariation BEFREE Association between polymorphisms of interleukin-17A G197A and interleukin-17F A7488G and risk of colorectal cancer. 29970680 2018
Malignant neoplasm of colon and/or rectum
0.030 GeneticVariation BEFREE We also observed a significant association between the AG genotype of IL-17A G197A SNP with increased risk of colorectal cancer as compared to AA genotype (P=0.001). 25680555 2015
Malignant neoplasm of colon and/or rectum
0.030 GeneticVariation BEFREE There was a significant difference between the genotype frequencies of IL17A G197A of control subjects (GG 68.34 % and GA + AA 31.65 %) and patients with colorectal cancer (GG 47.05 % and GA + AA 52.94 %) (p = 0.001 with odds ratio (OR) 2.45 (1.43-4.11)). 24699997 2014
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.020 GeneticVariation BEFREE The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. 26843459 2016
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.020 GeneticVariation BEFREE The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. 26843459 2016
Chronic Periodontitis
CUI: C0266929
Disease: Chronic Periodontitis
0.020 GeneticVariation BEFREE A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. 26339129 2015
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.020 GeneticVariation BEFREE The present meta-analysis showed the IL- 17A G197A polymorphism is associated with a significantly increased risk for specific forms of cancer, especially in gastric cancer. 24965422 2014
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.020 GeneticVariation BEFREE The present meta-analysis showed the IL- 17A G197A polymorphism is associated with a significantly increased risk for specific forms of cancer, especially in gastric cancer. 24965422 2014
Chronic Periodontitis
CUI: C0266929
Disease: Chronic Periodontitis
0.020 GeneticVariation BEFREE Our aim was to evaluate the association between periodontal status and the polymorphisms IL-17A G197A and IL-17F C7488T in subjects with CP along with their impact on levels of inflammatory mediators. 23304063 2012
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE In conclusion, OPN 9250 C/T and IL-17A 197 G/A genes polymorphisms and their serum levels seemed to have a role in pathogenesis of SLE. 30898714 2019
Leprosy
CUI: C0023343
Disease: Leprosy
0.010 GeneticVariation BEFREE We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. 30303246 2019
Lichen Planus, Oral
CUI: C0206139
Disease: Lichen Planus, Oral
0.010 GeneticVariation BEFREE IL17A G197A is associated with a higher susceptibility of developing OLP and these patients seem to present a considerable increase in IL17A serum levels. 28741807 2018
Malignant neoplasm of larynx
CUI: C0007107
Disease: Malignant neoplasm of larynx
0.010 GeneticVariation BEFREE In conclusion, the rs2275913 IL-17A (197 G/A) is associated with the incidence and development of laryngeal cancer in the Chinese population, and the AA and GA+AA genotypes harbor a high laryngeal cancer risk. 28362993 2017