Crohn Disease
|
|
0.720 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
Behcet Syndrome
|
|
0.820 |
GeneticVariation
|
BEFREE |
An IL23R-IL12RB2 intergenic SNP rs1495965 was significantly associated with BD risk (OR (95% CI) = 1.5 (1.3, 1.7), P = 2.5 × 10<sup>-7</sup>) in the pooled meta-analysis of the discovery (1.4 (1.2, 1.7), P = 4.9 × 10<sup>-7</sup>) and replication (1.9 (1.3, 2.6), P = 6.0 × 10<sup>-4</sup>) phases.
|
29017598 |
2017 |
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Eight IL23R gene polymorphisms (rs1,004,819, rs7,517,847, rs10,489,629, rs11,209,026, rs1,343,151, rs10,889,677, rs11,209,032, and rs1,495,965) were selected among the 10 most associated SNPs from the IBD study.
|
17678723 |
2007 |
Anterior uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain.
|
24312163 |
2013 |
Acute anterior uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain.
|
24312163 |
2013 |
Behcet Syndrome
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
Behcet Syndrome
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians.
|
27902482 |
2017 |
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, meta-analysis revealed no association between the four alleles of the rs2201841, rs1004819, rs1495965 and rs1343151 polymorphisms and the risk of developing UC in Caucasian and Asian populations.
|
25497273 |
2015 |
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Patients with the homozygous G allele of rs1495965 showed higher CD risk than those with other genotypes (GG vs. AA: OR, 2.256; 95% CI, 1.136-4.478; <i>p</i> = 0.019; GG vs. GA+AA: OR, 2.000; 95% CI, 1.175-3.404; <i>p</i> = 0.010).
|
31799225 |
2019 |
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Seven single nucleotide polymorphisms (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032, and rs1495965) were selected for genotyping among previously reported variants used in a genome-wide association study of inflammatory bowel disease.
|
19306001 |
2009 |
Behcet's uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis and Vary Between Populations.
|
29792538 |
2019 |
Behcet Syndrome
|
|
0.820 |
GeneticVariation
|
BEFREE |
SNPs rs10489629, rs1343151, and rs1495965 were also significantly associated with BD in all tests performed.
|
22378604 |
2012 |
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study indicates that minor allele carriers of rs1004819, rs1495965, and rs2201841 are susceptible to AS.
|
29944013 |
2018 |
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Two IL23R gene variants, an intronic SNP rs1004819 and intergenic SNP rs1495465, showed significant associations with CD; the adjusted odds ratio (aOR) for rs1004819 was 1.822 (95% confidence interval [CI] = 1.164-2.852, P = 0.009) and aOR for rs1495965 was 1.650 (95% CI = 1.102-2.471, P = 0.015).
|
19334001 |
2009 |