|
Immune thrombocytopenic purpura
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
|
26950245 |
2016 |
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our work provides preliminary information for a standardized method potentially useful for genotyping rs153109, and suggests its utility as a candidate approach to evaluate IL-27 p28 polymorphisms as additional clinical predictors of response to therapies in HCV infected patients.
|
25236666 |
2014 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
|
30694795 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Cryptorchidism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele and A/G genotype of rs153109 polymorphisms contribute to increase cryptorchidism susceptibility, and G allele and T/G genotype of rs17855750 also contribute to increase cryptorchidism susceptibility, which implies that these allele and genotypes may be risk factors for the development of cryptorchidism.
|
25988814 |
2016 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the association between a potentially functional polymorphism (rs153109, -964A>G) at the promoter of IL-27 and the risk of breast cancer in a Chinese population.
|
25146683 |
2014 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the association between a potentially functional polymorphism (rs153109, -964A>G) at the promoter of IL-27 and the risk of breast cancer in a Chinese population.
|
25146683 |
2014 |
|
Papillary thyroid carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between a potentially functional polymorphism (rs153109, -964A > G) in the promoter region of interleukin-27 (IL-27) gene and the risk of papillary thyroid cancer (PTC) in a Chinese population.
|
25994572 |
2015 |
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study examined the role of both (-964 A/G) single-nucleotide polymorphism (SNP) of IL-27p28 rs153109 and (-308 G/A) SNP of TNF-α rs1800629 on the progression of HCV infection in genotype 4a infected patients.
|
30204505 |
2019 |
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study investigated the potential role of (-964 A/G) SNP in the promoter region of IL-27p28 gene (alleles rs153109) on the outcome of HCV infection among genotype 4a infected patients.
|
27221901 |
2016 |
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
|
26161702 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
|
26161702 |
2015 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
|
27929666 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
|
27929666 |
2017 |
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
This method has been applied in a preliminary study on patients with chronic hepatitis C to provide information for a standardized assay useful to genotyping of rs153109 SNPs of IL-27p28.
|
25236666 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that IL-27p28 polymorphisms rs153109 and rs17855750 are likely involved in AR susceptibility, making them potentially useful genetic biomarkers for AR susceptibility in the Chinese Han population.
|
25075448 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
We did not find differences in genotype and allele frequencies of the IL-12B rs3212227 and IL-27 rs153109 and rs181206 variants between patients with SLE and controls.
|
27059274 |
2016 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |