|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study examined the role of both (-964 A/G) single-nucleotide polymorphism (SNP) of IL-27p28 rs153109 and (-308 G/A) SNP of TNF-α rs1800629 on the progression of HCV infection in genotype 4a infected patients.
|
30204505 |
2019 |
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present study investigated the potential role of (-964 A/G) SNP in the promoter region of IL-27p28 gene (alleles rs153109) on the outcome of HCV infection among genotype 4a infected patients.
|
27221901 |
2016 |
|
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our work provides preliminary information for a standardized method potentially useful for genotyping rs153109, and suggests its utility as a candidate approach to evaluate IL-27 p28 polymorphisms as additional clinical predictors of response to therapies in HCV infected patients.
|
25236666 |
2014 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data demonstrated that the genetic variant rs153109 in the 5' upstream region of IL-27 is significantly associated with UC in Chinese Han individuals.
|
28069403 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
|
27929666 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
We did not find differences in genotype and allele frequencies of the IL-12B rs3212227 and IL-27 rs153109 and rs181206 variants between patients with SLE and controls.
|
27059274 |
2016 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
|
Immune thrombocytopenic purpura
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
|
26950245 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
|
26950245 |
2016 |
|
Papillary thyroid carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between a potentially functional polymorphism (rs153109, -964A > G) in the promoter region of interleukin-27 (IL-27) gene and the risk of papillary thyroid cancer (PTC) in a Chinese population.
|
25994572 |
2015 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
|
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
|
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified.
|
26303036 |
2015 |
|
Immune thrombocytopenic purpura
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.
|
23937109 |
2013 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
|
30694795 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the association of IL-27 rs153109 and rs17855750 polymorphisms with risk of ALL development and their impact on EFS suggested an important role for this cytokine in biology and response to ALL therapy.
|
28828696 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the association of IL-27 rs153109 and rs17855750 polymorphisms with risk of ALL development and their impact on EFS suggested an important role for this cytokine in biology and response to ALL therapy.
|
28828696 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of IL-27 rs153109 and rs17855750 Polymorphisms with Risk and Response to Therapy in Acute Lymphoblastic Leukemia.
|
28828696 |
2018 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the association of IL-27 rs153109 and rs17855750 polymorphisms with risk of ALL development and their impact on EFS suggested an important role for this cytokine in biology and response to ALL therapy.
|
28828696 |
2018 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association between the IL-27 single nucleotide polymorphism (SNP) rs153109</span> and AF was found in Chinese Han population.
|
28055231 |
2017 |