|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Patient-control haplotype analyses using the SHEsis online haplotype analysis software showed that the G allele frequency of rs1544410 in the T2DM group was higher than that in the control group [odds ratio (OR) = 1.738, 95% confidence interval (CI) = 1.055-2.865], suggesting that the G allele is a risk factor of T2DM in the Chinese Han population.
|
25501168 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Results showed T2DM to be significantly associated with the VDR Taq1 (rs731236-AG) and Bsm-I (rs1544410-CT) genotypes, and the VDR rs1544410-T allele.
|
22219324 |
2012 |
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that VDR rs1544410, rs2228570 and rs731236 variants might serve as genetic biomarkers of TB in certain populations.
|
30822458 |
2019 |
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Pooled overall analyses suggested that VDR rs1544410 (dominant model: P = 0.02; allele model: P = 0.03) and rs731236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB.
|
30987490 |
2019 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population.
|
29343214 |
2018 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance.
|
28617856 |
2017 |
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, β = 0.086 and p = 0.028, β = 0.072, respectively).
|
25020064 |
2014 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analyses by type of disease, we confirmed positive results for rs1544410 BsmI polymorphism in both asthma and atopic dermatitis, and for rs731236 TaqI polymorphism in atopic dermatitis.
|
31752548 |
2020 |
|
Dermatitis, Atopic
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analyses by type of disease, we confirmed positive results for rs1544410 BsmI polymorphism in both asthma and atopic dermatitis, and for rs731236 TaqI polymorphism in atopic dermatitis.
|
31752548 |
2020 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
Eczema
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analyses by type of disease, we confirmed positive results for rs1544410 BsmI polymorphism in both asthma and atopic dermatitis, and for rs731236 TaqI polymorphism in atopic dermatitis.
|
31752548 |
2020 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis.
|
31740220 |
2019 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNPs rs1544410 and rs7975232 were mainly implicated in the increased risk of MetS in the Thai population.
|
30045441 |
2019 |
|
Nephrolithiasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
After analyzing 23 publications, we observed that BsmI polymorphism (rs1544410) has a protective association against nephrolithiasis (Allelic model: OR = 0.84, CI 95% 0.73-0.96, Z p-value 0.015; homozygous model: OR = 0.72, CI 95% 0.54-0.97, Z p-value 0.033).
|
31212049 |
2019 |
|
Parkinson Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
No significant association was found between rs7975232 or rs1544410 and PD.
|
30763651 |
2019 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The VDR rs1544410G>A gene is a strong risk factor for CAD (OR = 1.28, p = 0.002) and the dominant genotype (T/G+G/G) of VDBP 7041 T>G SNP plays a protective role (OR = 0.67, p = 0.003) in AMVC development in studied population.
|
31359379 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
In contrast, the VDR gene ApaI (G > T, rs7975232) and BsmI (A > G, rs1544410) polymorphisms did not show association with T1DM.
|
30845908 |
2019 |
|
Kidney Calculi
|
|
0.020 |
GeneticVariation
|
BEFREE |
After analyzing 23 publications, we observed that BsmI polymorphism (rs1544410) has a protective association against nephrolithiasis (Allelic model: OR = 0.84, CI 95% 0.73-0.96, Z p-value 0.015; homozygous model: OR = 0.72, CI 95% 0.54-0.97, Z p-value 0.033).
|
31212049 |
2019 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association between vitamin D receptor gene <i>Bsm I</i> (rs1544410) polymorphism and prostate cancer (PCa) risk has been investigated by numerous previous studies, which yielded inconsistent results.
|
30122987 |
2018 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two SNPs in VDR were associated with GD: rs10735810 (OR = 1.36, 95% CI: 1.02-1.36, <i>p</i> = 0.02) and rs1544410 (OR = 1.47, 95% CI: 1.03-1.47, <i>p</i> = 0.02).
|
29594051 |
2018 |
|
Osteoporosis, Postmenopausal
|
|
0.020 |
GeneticVariation
|
BEFREE |
For the bearers of C-G-C haplotype (consisting of rs7975232, rs1544410, and rs731236 unfavorable alleles), the risk of PMO was significantly higher (OR = 4.7, 95% CI 2.8-8.1, <i>p</i> < 0.0001) compared to controls.
|
29922235 |
2018 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association between vitamin D receptor gene <i>Bsm I</i> (rs1544410) polymorphism and prostate cancer (PCa) risk has been investigated by numerous previous studies, which yielded inconsistent results.
|
30122987 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, for detecting clinical risk of OC, heterozygote models with the rs1544410 (BsmI) polymorphism is likely the best genetic model for detecting the risk of OC in Caucasian patients.
|
30059751 |
2018 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
However VDR gene polymorphisms did not seem to be associated with an increased risk of MS. <b>Conclusions:</b> Vitamin D deficiency, rs7975232, and rs1544410 VDR gene variants are associated with MS parameters in Russian middle-aged women.
|
30166978 |
2018 |