|
Colorectal Carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
The polymorphisms Arg326Gln and Gln276Pro of the PTPRJ gene are not associated with an increased risk of cancer except for the Arg326Gln polymorphism in colorectal cancer.
|
30661225 |
2019 |
|
Colorectal Carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
To determine if variants or haplotype in PTPRJ confer protective or risk effects for colorectal cancer (CRC), we genotyped rs1566734 and six additional PTPRJ haplotype tagging single nucleotide polymorphisms (SNP) in CRC cases and controls from the Molecular Epidemiology of Colorectal Cancer study.
|
18843023 |
2008 |
|
Colorectal Carcinoma
|
|
0.730 |
GeneticVariation
|
BEFREE |
The importance of the PTPRJ- c.827A>C SNP appears to be limited in familial CRC.
|
16258161 |
2005 |
|
Colorectal Carcinoma
|
|
0.730 |
CausalMutation
|
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
The polymorphisms Arg326Gln and Gln276Pro of the PTPRJ gene are not associated with an increased risk of cancer except for the Arg326Gln polymorphism in colorectal cancer.
|
30661225 |
2019 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
The polymorphisms Arg326Gln and Gln276Pro of the PTPRJ gene are not associated with an increased risk of cancer except for the Arg326Gln polymorphism in colorectal cancer.
|
30661225 |
2019 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Increased risks were observed with one or more of the combination genotypes of Gln276Pro and Arg326Gln in PTPRJ for most cancer types (aOR range 10.13-55.08, Bonferroni-corrected P = 0.0454-7.20 x 10(-9)).
|
19672627 |
2010 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Increased risks were observed with one or more of the combination genotypes of Gln276Pro and Arg326Gln in PTPRJ for most cancer types (aOR range 10.13-55.08, Bonferroni-corrected P = 0.0454-7.20 x 10(-9)).
|
19672627 |
2010 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
There was no evidence for cancer risk with rs1566734 in 1,897 cases and 1,954 controls with a homozygote odds ratio of 1.09 and 95% confidence interval of 0.85 to 1.39.
|
18843023 |
2008 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
There was no evidence for cancer risk with rs1566734 in 1,897 cases and 1,954 controls with a homozygote odds ratio of 1.09 and 95% confidence interval of 0.85 to 1.39.
|
18843023 |
2008 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphisms Arg326Gln and Gln276Pro of the PTPRJ gene are not associated with an increased risk of cancer except for the Arg326Gln polymorphism in colorectal cancer.
|
30661225 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
To determine if variants or haplotype in PTPRJ confer protective or risk effects for colorectal cancer (CRC), we genotyped rs1566734 and six additional PTPRJ haplotype tagging single nucleotide polymorphisms (SNP) in CRC cases and controls from the Molecular Epidemiology of Colorectal Cancer study.
|
18843023 |
2008 |
|
Papillary thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a non-significant increased frequency of homozygotes for Gln276Pro polymorphism in PTC cases in two distinct Caucasian populations.
|
20823296 |
2010 |
|
Colorectal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ptprj was identified as a strong candidate gene for mouse locus susceptibility to colorectal cancer 1, and one variant, rs1566734, showed evidence of preferential allelic imbalance in human colorectal tumors.
|
18843023 |
2008 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the Gln276Pro polymorphism, located in the extracellular region of the gene, seems to play a critical role in susceptibility to some human neoplasias.
|
15378013 |
2004 |
|
Thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrate these features by typing two SNPs (Q276P and R326Q) in the human phosphatase gene PTPrj, which has been implicated in the aetiology of colon, lung, breast and thyroid cancers.
|
15384144 |
2004 |
|
Malignant neoplasm of thyroid
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrate these features by typing two SNPs (Q276P and R326Q) in the human phosphatase gene PTPrj, which has been implicated in the aetiology of colon, lung, breast and thyroid cancers.
|
15384144 |
2004 |