rs157582, TOMM40

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation BEFREE Moreover, rs56131196 (P = 1.96 × 10<sup>-454</sup>) and rs157582 (P = 9.70 × 10<sup>-434</sup>) were risk loci for Alzheimer's disease. 31760383 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASCAT Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease. 22832961 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASDB Genome-wide association analysis of age-at-onset in Alzheimer's disease. 22005931 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.810 GeneticVariation GWASDB Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. 20885792 2010
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.800 GeneticVariation GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.800 GeneticVariation GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.700 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
Memory performance
CUI: C1285654
Disease: Memory performance
0.700 GeneticVariation GWASCAT Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. 28800603 2017
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.700 GeneticVariation GWASCAT Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations. 26582766 2016
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.700 GeneticVariation GWASDB Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 23844046 2013
Acute transient psychotic disorder
CUI: C0349198
Disease: Acute transient psychotic disorder
0.700 GeneticVariation GWASCAT Genome-wide association study of Alzheimer's disease with psychotic symptoms. 22005930 2012
Mental deterioration
CUI: C0234985
Disease: Mental deterioration
0.010 GeneticVariation BEFREE The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline. 31760383 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.010 GeneticVariation BEFREE The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline. 31760383 2019