|
Interleukin 1 Beta Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
|
30206230 |
2018 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia.
|
28083609 |
2016 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
|
24155145 |
2014 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia.
|
22763186 |
2012 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032).
|
21843369 |
2011 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The combined allele-wise odds ratio (OR) for schizophrenia of the rs16944 (IL1B gene; T-511C) polymorphism was 0.86 (95% CI: 0.77to 0.96).When applying stratified analysis to this polymorphism, the pooled allele-wise OR was 0.88 (95% CI, 0.79 to 0.97) in 10 population-based studies and 0.85 (95% CI: 0.73 to 0.99) in Caucasian samples.
|
20347268 |
2010 |
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the expression level of IL-1B in MS patients increased 3.336 times more than controls in PBMCs but the rs16944 SNP in the promoter region of IL-1B did not affect the expression level of this gene and there was not association of this SNP with MS in the examined population.
|
24867167 |
2014 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
No association was found between the IL-1α -889 (rs1800587), IL-1α +4,845 (rs17561), IL-1β -511 (rs16944), IL-1β +3,953 (rs1143634), IL-1ra variable number tandem repeat (VNTR) polymorphisms and MS risk.
|
23052182 |
2013 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated.
|
21621860 |
2011 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
With respect to MS, IL-1 beta (-511 C/T; rs16944), IL-1 beta (+3954 C/T; rs1143634), IL-1 alpha (-889 C/T; rs1800587), IL-1 alpha (+4845 G/T; rs17561), and the variable number of tandem repeats in intron 2 of the IL-1 receptor antagonist (IL-1RN) gene polymorphisms have been studied in different ethnic groups, leading to conflicting results.
|
20192980 |
2010 |
|
Depressive Symptoms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Chronic Periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis.
|
30939298 |
2019 |
|
Chronic Periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The subgroup analysis stratified by ethnicity showed a weak association between the IL-1<i>β</i> polymorphism (rs16944</span>) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017-1.758, <i>P</i> = 0.037).
|
30647799 |
2018 |
|
Depressive Symptoms
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, the effect of rs16944 A allele was reversed in a subsample with low-exposure to life stress, suggesting a protective effect against depressive symptoms, in the post hoc analysis.
|
26891860 |
2016 |
|
Depressive Symptoms
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate a trio of functional SNPs in the promoter regions of IL6 (-174G>C, rs1800795), IL1β (-511C>T, rs16944), and TNF (-308G>A, rs1800629) as moderators of the relationship between chronic stress exposure and elevations in depressive symptoms.
|
25596176 |
2015 |
|
Chronic Periodontitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Seventy-four patients with VD of whom 36 had CP were genotyped for single nucleotide polymorphisms in the IL1A -889 (rs1800587), IL1B +3954 (rs1143634) and IL1B at -511 (rs16944) genes and for VNTR polymorphisms in the IL1RN gene.
|
24612355 |
2014 |
|
Depressed mood
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our result revealed IL-1B rs1143627-AA (OR = 1.98, p = 0.029) and rs16944-GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer.
|
31222982 |
2019 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our result revealed IL-1B rs1143627-AA (OR = 1.98, p = 0.029) and rs16944-GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer.
|
31222982 |
2019 |
|
Periodontal Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results of this study suggest there is no association between IL-1ß rs1143634 and rs16944 polymorphisms and PD.
|
30445239 |
2019 |
|
Mental Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Depressive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Febrile Convulsions
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings of our meta-analysis suggest that the IL-1B rs16944 polymorphism may be an important genetic determinant for FS in Caucasian and Asian populations.
|
29808330 |
2018 |
|
Febrile Convulsions
|
|
0.020 |
GeneticVariation
|
BEFREE |
Expression of these cytokines can be modulated by polymorphisms such as rs16944 and rs1800629, respectively, both of which have been associated with febrile seizures (FS) and MTLE-HS development.
|
28675059 |
2018 |