|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the distribution of haplotypes and genotype combination in our cohort indicated increased RA risk in individuals carrying the rs17860508/rs3212227 2/A haplotype or 2.2/AC+CC combination, while 1/A haplotype or 1.1/AA combination may be protective for RA.
|
31161840 |
2020 |
|
Malaria
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL-12 genotypes (IL-12b rs2288831/rs17860508) and the haplotype CGTTAGAG distribution were related to malaria susceptibility and background IL-12 levels.
|
30022038 |
2018 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the role of single nucleotide polymorphisms (SNPs) (rs3212227 (A/C) and rs17860508 (CTCTAA/GC)) of the IL-12B gene in the genetic susceptibility to RA and in the severity of the disease.
|
27896842 |
2017 |
|
Malaria
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL12Bpro (rs17860508) and IL12B 3' UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai-Myanmar border in northwest Thailand.
|
20387064 |
2010 |
|
Multiple Sclerosis, Relapsing-Remitting
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to evaluate whether two polymorphisms in IL12B gene, rs17860508 and rs3212227, are associated with RRMS, and to define their function effect on serum level of IL-12p40 and IL-23 and degree of disability in RRMS cases.
|
30554348 |
2019 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association was found for the rs17860508 polymorphism with AS under the allelic, the dominant, and the co-dominant models.
|
30443744 |
2019 |
|
Musculoskeletal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we evaluated the implication of IL12Bpro (rs17860508) and IL12B 3' UTR A/C single nucleotide polymorphisms (SNPs) (rs3212227) for the ankylosing spondylitis (AS) development and the impact of IL12B genetic variations on IL-23 and IL-12p40 production and musculoskeletal disease characteristics.
|
30443744 |
2019 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Defects in dendritic cells (DCs) recruitment, maturation and cytokine release are a hallmark of the CRC strategy to escape immune surveillance.The purpose of our study was to evaluate the possible role of IL-12B polymorphism in the promoter region of the IL-12B gene (rs17860508) as a genetic factor contributing to the risk for CRC development.
|
29155516 |
2019 |
|
Endometriosis of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the CTCTAA/CTCTAA genotype, the GC/GC and GC/CTCTAA genotypes of rs17860508 could significantly increase the risk of ovarian endometriosis development (OR = 1.58, 95% CI = 1.19-2.09; OR = 1.37, 95% CI = 1.08-1.74, respectively).
|
29738836 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results revealed that IL-12B rs17860508 and IL-27 haplotype CG are genetic risk factors for SLE and that both IL-12B rs17860508 and rs3212227 predict disease phenotype.
|
27059274 |
2016 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL12Bpro (rs17860508) and IL12B 3' UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai-Myanmar border in northwest Thailand.
|
20387064 |
2010 |
|
Malaria, Falciparum
|
|
0.010 |
GeneticVariation
|
BEFREE |
To examine whether the CTCTAA allele is associated with susceptibility to cerebral malaria in Asian populations, 303 Thai patients with Plasmodium falciparum malaria (109 cerebral malaria and 194 mild malaria patients) were genotyped for rs17860508 by PCR-direct sequencing.
|
20003322 |
2009 |
|
Malaria, Cerebral
|
|
0.010 |
GeneticVariation
|
BEFREE |
To examine whether the CTCTAA allele is associated with susceptibility to cerebral malaria in Asian populations, 303 Thai patients with Plasmodium falciparum malaria (109 cerebral malaria and 194 mild malaria patients) were genotyped for rs17860508 by PCR-direct sequencing.
|
20003322 |
2009 |