|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01-1.08; OR, 1.08; 95%CI, 1.05-1.12 and OR, 1.05; 95%CI, 1.02-1.08, respectively).
|
23840762 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASCAT |
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
|
23575436 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
GWASDB |
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
|
23575436 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The GCK rs1799884 A allele was significantly associated with decreased HOMA-B (p([add]) = 0.0005), but not with type 2 diabetes or IFG.
|
19241058 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.830 |
GeneticVariation
|
BEFREE |
The SNP rs1799884 in the GCK promoter was associated with elevated fasting plasma glucose (fPG) concentrations that remained unchanged during the follow-up period (P = 0.4; SE 0.004 [-0.003-0.007]) but did not predict future type 2 diabetes (HR 0.9 [0.8-1.0], P = 0.1).
|
18332101 |
2008 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
21909109 |
2011 |
|
Fasting blood sugar result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|
21909109 |
2011 |
|
Gestational Diabetes
|
|
0.050 |
GeneticVariation
|
BEFREE |
In the case of the GCK rs1799884 polymorphism, there was a predominance of the T allele in women with GDM; however, this association reached only borderline statistical significance (p=0.08).
|
28359772 |
2017 |
|
Gestational Diabetes
|
|
0.050 |
GeneticVariation
|
BEFREE |
These findings indicate that the association of sausage consumption with GDM risk can be determined based on the number of risk alleles of rs10830963 in <i>MTNR1B</i> and rs1799884 in <i>GCK</i>.
|
29340108 |
2017 |
|
Gestational Diabetes
|
|
0.050 |
GeneticVariation
|
BEFREE |
The most important risk alleles associated with GDM were rs10830963/G of MTNR1B (OR = 1.84/1.64 [IADPSG/m'99WHO], p = 0.0007/0.006), rs7754840/C (OR = 1.51/NS, p = 0.016) of CDKAL1 and rs1799884/T (OR = 1.4/1.56, p = 0.04/0.006) of GCK.
|
28072873 |
2017 |
|
Gestational Diabetes
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis.
|
25633883 |
2015 |
|
Gestational Diabetes
|
|
0.050 |
GeneticVariation
|
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GCKR rs780094 and GCK rs1799884 polymorphisms have been reported to be associated with dyslipidaemia and type 2 diabetes in white Europeans.
|
19241058 |
2009 |