|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
(3) The single-nucleotide polymorphisms (SNP) G691S in exon 11 (rs1799939), S904S in exon 15 (rs1800863), and rs2075912 and rs2565200 in the 3'-untranslated region of the RET proto-oncogene are in complete linkage disequilibrium (D' = 1, r2 = 1); no correlation of these SNP and MTC was observed in this pedigree.
|
27798940 |
2017 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
The modifier role of RET-G691S polymorphism in hereditary medullary thyroid carcinoma: functional characterization and expression/penetrance studies.
|
25887804 |
2015 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
In silico analyses on G691S confirmed a change of the phosphorylation pattern that might account for the enhanced signaling transduction previously reported for G691S in several cancers, thus also explaining its overrepresentation in MTCs.
|
23180660 |
2013 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior.
|
22345297 |
2012 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer.
|
22111543 |
2012 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs in exon 11 (G691S) and exon 15 (S904S) appear to influence the development of MTC.
|
21134561 |
2010 |
|
Medullary carcinoma of thyroid
|
|
0.070 |
GeneticVariation
|
BEFREE |
The prevalence of the RET polymorphism G691S of exon 11 is higher in patients with medullary thyroid carcinoma (MTC) as compared to the general population.
|
19411807 |
2009 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior.
|
22345297 |
2012 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We suggest that molecular profiling of each patient's tumor for G691S RET SNP, potentially CXCR2 SNP, and also other yet-to-be identified SNP associated with pancreatic cancer will allow for both improved understanding of individual prognosis and allow for utilization of more personalized, targeted adjuvant therapies.
|
19057948 |
2009 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The RET (rearranged during transfection) proto-oncogene G691S variant is over-represented in the germline of patients with sporadic medullary thyroid carcinoma (sMTC) vs. normal controls but so far is not associated with any medical or pathological features of the tumour.
|
18331611 |
2008 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated LOH for three RET SNPs (G691S, S904S, and L769L) in tumor and normal tissue from 46 patients from Ukraine and Belarus who were exposed to radioactive fallout following the Chernobyl nuclear accident and were operated for papillary thyroid carcinoma between 1995 and 2000.
|
15753666 |
2005 |
|
Papillary thyroid carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, RET gene G691S/S904S polymorphisms were over-represented and L769L polymorphism was under-represented in PTC and FTC patients.
|
25736215 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Occurrence of medullary thyroid carcinoma, bronchial carcinoid tumor, and papillary thyroid carcinoma in a family bearing the RET G691S polymorphism.
|
19411807 |
2009 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data demonstrate that the RET G691S variant could modulate the age of onset of sMTC as demonstrated previously for familial tumours.
|
18331611 |
2008 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
|
0.030 |
GeneticVariation
|
BEFREE |
On the other hand, the frequency and distribution of G691S/S904S variants were similar in both groups of study, leading to exclude their role in sMTC in our series.
|
16646689 |
2006 |
|
Papillary thyroid carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated LOH for three RET SNPs (G691S, S904S, and L769L) in tumor and normal tissue from 46 patients from Ukraine and Belarus who were exposed to radioactive fallout following the Chernobyl nuclear accident and were operated for papillary thyroid carcinoma between 1995 and 2000.
|
15753666 |
2005 |
|
THYROID CARCINOMA, SPORADIC MEDULLARY
|
|
0.030 |
GeneticVariation
|
BEFREE |
RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population.
|
15240649 |
2004 |
|
Pheochromocytoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings propose a classification of 15 of the 26 VUS in RET without any well-defined risk profiles and suggest that the G691S SNP, or a combination of SNPs, may be associated with the development of PHEO.
|
28946813 |
2017 |
|
Adrenal Gland Pheochromocytoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings propose a classification of 15 of the 26 VUS in RET without any well-defined risk profiles and suggest that the G691S SNP, or a combination of SNPs, may be associated with the development of PHEO.
|
28946813 |
2017 |
|
Desmoplastic melanoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome.
|
27543214 |
2016 |
|
Desmoplastic melanoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Apart from RET G691S our findings demonstrate absence of activating driver mutations in pure desmoplastic melanoma beyond previously investigated oncogenes (BRAF, NRAS, and KIT).
|
25769001 |
2015 |
|
Thyroid Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC.
|
26191299 |
2015 |
|
Pheochromocytoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We did not observe any association between the frequencies of L769L, S836S, or S904S/G691S variants and PHEO development (all P>0.05).
|
24616415 |
2014 |
|
Adrenal Gland Pheochromocytoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We did not observe any association between the frequencies of L769L, S836S, or S904S/G691S variants and PHEO development (all P>0.05).
|
24616415 |
2014 |
|
Cutaneous Melanoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A polymorphism, RETp (G691S), in the intracellular juxtamembrane domain of RET, which enhances signaling by glial cell-derived neurotrophic factor has been described and studied previously in pancreatic cancer, medullary thyroid cancer, the multiple endocrine neoplasia 2 syndromes, and recently in cutaneous malignant melanoma.
|
22189301 |
2012 |