|
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
|
28714974 |
2017 |
|
Coronary Artery Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Our data suggest that the G473A polymorphism of LOX gene is associated with increased susceptibility to CAD.
|
21612403 |
2011 |
|
Keratoconus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our study demonstrated that the LOX rs1800449 genotypes (AA and GA + AA) and allele (A) appears to confer risk for susceptibility to keratoconus.
|
24502826 |
2015 |
|
Keratoconus
|
|
0.030 |
GeneticVariation
|
BEFREE |
In contrast, our study lacked sufficient evidences to support the association of rs1800449/rs2288393 with keratoconus across populations.
|
26713757 |
2015 |
|
Keratoconus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Sequencing of LOX exons in a subset of keratoconus patients identified two polymorphisms, rs1800449 and rs2288393, located in LOX transcripts I and II, associated with keratoconus in case-control and family samples with a meta P value of 0.02.
|
22661479 |
2012 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population.
|
27367711 |
2016 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Thus, LOX G473A polymorphism positively correlates with carcinogenesis and it may be used as an ideal intrinsic biomarker for prediction or diagnosis of carcinogenesis in humans.
|
27367711 |
2016 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
LOX G473A polymorphism apparently elevated human sensitivity to cigarette smoking carcinogens for eliciting cancers in the lung and colon only.
|
27367711 |
2016 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis and case-control study of CRC observed convincing association of LOX G473A polymorphism with cancer risk in Asians; our study would contribute to complete elucidation of carcinogenesis.
|
25112403 |
2015 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis and case-control study of CRC observed convincing association of LOX G473A polymorphism with cancer risk in Asians; our study would contribute to complete elucidation of carcinogenesis.
|
25112403 |
2015 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Overall, this meta-analysis and case-control study of CRC observed convincing association of LOX G473A polymorphism with cancer risk in Asians; our study would contribute to complete elucidation of carcinogenesis.
|
25112403 |
2015 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
LOX mRNA expression was significantly elevated in tumours of patients older than 55 years, postmenopausal patients, estrogen receptor positive tumours, and p53 negative tumours, but was unaffected by G473A genotype in tumours and breast cancer cell lines.
|
25141126 |
2014 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
LOX mRNA expression was significantly elevated in tumours of patients older than 55 years, postmenopausal patients, estrogen receptor positive tumours, and p53 negative tumours, but was unaffected by G473A genotype in tumours and breast cancer cell lines.
|
25141126 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that LOX G473A polymorphism is a new risk factor for ovarian cancer and that LOX protein might be a possible therapeutic target in ovarian cancer.
|
22906264 |
2012 |
|
ovarian neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the G473A polymorphism of the LOX gene is associated with increased susceptibility to ovarian cancer.
|
22533780 |
2012 |
|
ovarian neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that LOX G473A polymorphism is a new risk factor for ovarian cancer and that LOX protein might be a possible therapeutic target in ovarian cancer.
|
22906264 |
2012 |
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the G473A polymorphism of the LOX gene is associated with increased susceptibility to ovarian cancer.
|
22533780 |
2012 |
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data suggest that the G473A polymorphism of the LOX gene is associated with increased susceptibility to ovarian cancer.
|
22533780 |
2012 |
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that LOX G473A polymorphism is a new risk factor for ovarian cancer and that LOX protein might be a possible therapeutic target in ovarian cancer.
|
22906264 |
2012 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a significant difference in the frequency of the LOX G473A genotype between the breast cancer and control groups.
|
20929399 |
2011 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a significant difference in the frequency of the LOX G473A genotype between the breast cancer and control groups.
|
20929399 |
2011 |
|
Diabetic foot ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding predicts that there is an association of LOX gene polymorphism (G473A) on diabetes and DFU patients when compared to that of healthy controls.
|
28522400 |
2017 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding predicts that there is an association of LOX gene polymorphism (G473A) on diabetes and DFU patients when compared to that of healthy controls.
|
28522400 |
2017 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding predicts that there is an association of LOX gene polymorphism (G473A) on diabetes and DFU patients when compared to that of healthy controls.
|
28522400 |
2017 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The relationship among the lysyl oxidase (LOX) G473A single nucleotide polymorphism (SNP), cigarette smoking and lung, colorectal, colon and rectum cancer susceptibility was studied in 200 cases of lung cancer, 335 cases of colorectal cancer including 130 cases of colon cancer and 205 cases of rectum cancer, and 335 healthy people in Tangshan, China.
|
27367711 |
2016 |