rs1800866, SIGMAR1

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.040 GeneticVariation BEFREE We performed a meta-analysis of the association between the functional Gln2Pro</span> polymorphism and schizophrenia using combined samples (1254 patients with schizophrenia and 1574 healthy controls) from previously published studies and our own additional samples (478 patients and 631 controls). 21549171 2011
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.040 GeneticVariation BEFREE We investigated the association between Sig-1R functional polymorphism (Gln2Pro) and brain function in schizophrenia. 19439245 2009
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.040 GeneticVariation BEFREE Our case-control study showed no significant association between the T-485 A, GC-241-240TT, Gln2Pro, and G620A (Arg211Gln) variants and schizophrenia and clinical characteristics. 15298647 2004
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.040 GeneticVariation BEFREE A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. 14567761 2003
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.020 GeneticVariation BEFREE A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). 28144920 2017
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.020 GeneticVariation BEFREE Our results suggest that rs1800866 in SIGMAR1 may play a role in the pathophysiology of MDD in the Japanese population. 20178807 2010
Chronic pain
CUI: C0150055
Disease: Chronic pain
0.010 GeneticVariation BEFREE This study indicates lack of association of SIGMAR1 -297G>T and 5A>C genetic variants to susceptibility to develop chronic pain, but significant modulation of somatosensory function in neuropathic pain patients. 30266269 2019
Neuralgia
CUI: C0027796
Disease: Neuralgia
0.010 GeneticVariation BEFREE This study indicates lack of association of SIGMAR1 -297G>T and 5A>C genetic variants to susceptibility to develop chronic pain, but significant modulation of somatosensory function in neuropathic pain patients. 30266269 2019
Central Nervous System Sensitization
CUI: C2938905
Disease: Central Nervous System Sensitization
0.010 GeneticVariation BEFREE Likewise for 5A>C the strongest genotype-associated differences observed were reduced peripheral (less heat hyperalgesia; P = .026) and central sensitization (lower mechanical pain sensitivity; P = .026) in variant compared to wild-type carriers. 30266269 2019
Mechanical pain
CUI: C0234252
Disease: Mechanical pain
0.010 GeneticVariation BEFREE Likewise for 5A>C the strongest genotype-associated differences observed were reduced peripheral (less heat hyperalgesia; P = .026) and central sensitization (lower mechanical pain sensitivity; P = .026) in variant compared to wild-type carriers. 30266269 2019
Hyperalgesia
CUI: C0020429
Disease: Hyperalgesia
0.010 GeneticVariation BEFREE Likewise for 5A>C the strongest genotype-associated differences observed were reduced peripheral (less heat hyperalgesia; P = .026) and central sensitization (lower mechanical pain sensitivity; P = .026) in variant compared to wild-type carriers. 30266269 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.010 GeneticVariation BEFREE We aimed to investigate the association between SIGMAR1 polymorphisms and late-onset AD, therefore we genotyped rs1799729 (GC-241-240TT) and rs1800866 (Q2P) in 322 Hungarian late-onset AD patients and 250 ethnically matched, elderly control individuals. 22561649 2012