|
Acquired Immunodeficiency Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of at least one copy of the T allele for the IL10 rs1800871 (as compared to no copies) was associated with decreased AIDS-NHL risk specific to lymphomas arising from the CNS (CC vs. CT/TT: OR = 0.3; 95% CI 0.1, 0.7) but not systemically (CC vs. CT/TT: OR = 1.0; 95% CI 0.5, 1.9) (Pheterogeneity = 0.03).
|
20299965 |
2010 |
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
|
Acute pyelonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymerase chain reaction with sequence-specific primers was used to analyse IL10 -1082A/G (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) SNPs in 147 children with acute pyelonephritis and 215 healthy controls.
|
24449078 |
2014 |
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of two copies of the 'low IL10' haplotype rs1800896_A/rs1800871_T/rs1800872_A was associated with decreased lymphoma risk that varied by number of copies (Ptrend = 0.02).
|
20299965 |
2010 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To further investigate the proposed association and to clarify the role of cytokines as a potential cause for AD susceptibility, we analyzed genotypes, allele distributions and haplotypes of IL10 promoter polymorphisms -1082 (rs1800896) and -819 (rs1800871) in an Italian sample of 222 sporadic AD patients and 179 normal controls.
|
17420099 |
2007 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To further investigate the proposed association and to clarify the role of cytokines as a potential cause for AD susceptibility, we analyzed genotypes, allele distributions and haplotypes of IL-10 promoter polymorphisms -1082 (rs1800896) and -819 (rs1800871) in a Mexican population: 986 normal controls and 221 cases divided as follows: 122 with Alzheimer disease (AD), 67 with (VaD) and 32 with mixed dementia (AD/VaD).
|
27474414 |
2016 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population.
|
26782404 |
2015 |
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, rs1544410 polymorphism within the VDR gene, E2 and E4 alleles within the apoE gene, rs6254 polymorphism within the PTH gene, and rs1800871 polymorphism within the IL10 gene may be associated with aortic stenosis with low level of evidence.
|
24903972 |
2014 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether single-base exchange polymorphisms -1082 G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872) at IL10 gene are associated with risk factors and early markers of atherosclerosis in young subjects.
|
19700159 |
2010 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study was conducted to evaluate the association of IL-10 (interleukin 10) and IL-17F (interleukin 17F) promoter polymorphisms (rs1800871, rs1800896 and rs1889570) with asthma and its clinical phenotypes including severity, atopic status, spirometric parameters, and response to treatment in south Indian population.
|
26108303 |
2015 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether single-base exchange polymorphisms -1082 G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872) at IL10 gene are associated with risk factors and early markers of atherosclerosis in young subjects.
|
19700159 |
2010 |
|
Autoimmune Chronic Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to assess the association between three IL10 promoter polymorphisms (rs1800896, rs1800871, and rs1800872) and the risk of autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis.
|
29694797 |
2018 |
|
Autoimmune hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to assess the association between three IL10 promoter polymorphisms (rs1800896, rs1800871, and rs1800872) and the risk of autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis.
|
29694797 |
2018 |
|
Autoimmune liver disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our meta-analysis strongly suggests that the IL10 rs1800896, rs1800871, and rs1800872 polymorphisms are not associated with the risk of autoimmune liver disease.
|
29694797 |
2018 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
|
20622879 |
2010 |
|
Behcet Syndrome
|
|
0.830 |
GeneticVariation
|
BEFREE |
Compared to the controls, an increased frequency of the rs1800871 T allele was observed in BD patients with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test.
|
26015771 |
2015 |
|
Behcet's uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>Results</i>: The risk allele, A, in rs1800871, of <i>IL-10</i> gene was highly prevalent in Behcet's uveitis and healthy control samples alike; highest among the Turkish groups.
|
29792538 |
2019 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis
|
30583340 |
2018 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that IL-10 rs1800896 and rs1800871 polymorphisms had no association with BC risk, while rs1800872 polymorphism had a decreased risk of BC in Caucasians.
|
24720854 |
2014 |