|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Tumor DNA was extracted from these biopsies and sequenced to analyze the rs1800925 polymorphism.
|
27167201 |
2016 |
|
Rhinitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043).
|
18037162 |
2008 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043).
|
18037162 |
2008 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although no SNP was associated with breast cancer risk among women of European descent, we found evidence for an association among East Asians for rs1800925 (IL-13) and breast cancer risk (OR = 2.08; 95% CI: 1.32-3.28; p = 0.000779), which remained statistically significant after multiple testing correction (padj = 0.0350).
|
30601841 |
2019 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although no SNP was associated with breast cancer risk among women of European descent, we found evidence for an association among East Asians for rs1800925 (IL-13) and breast cancer risk (OR = 2.08; 95% CI: 1.32-3.28; p = 0.000779), which remained statistically significant after multiple testing correction (padj = 0.0350).
|
30601841 |
2019 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Although this SNP (rs1800925) was not associated with asthma exacerbations among all white children in CAMP, it was associated with increased risk of asthma exacerbations among children on inhaled corticosteroids (P = .02).
|
17561245 |
2007 |
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation
|
BEFREE |
An additional SNP, rs1800925, was genotyped only in the PsA and PsC groups.
|
21613309 |
2011 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
An additional SNP, rs1800925, was genotyped only in the PsA and PsC groups.
|
21613309 |
2011 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD.
|
24286397 |
2013 |
|
Appendicitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation
|
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
Psoriasis vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Can an IL13 -1112 C/T (rs1800925) polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer?
|
27167201 |
2016 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis.
|
22023794 |
2011 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) <25.00.
|
27323078 |
2016 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
|
29687183 |
2018 |
|
Rhinitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
IL13 C-1111T (rs1800925) was significantly associated with rhinitis and atopic phenotypes in rhinitis trios that were not affected by clinical asthma.
|
20484924 |
2010 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 C-1111T (rs1800925) was significantly associated with rhinitis and atopic phenotypes in rhinitis trios that were not affected by clinical asthma.
|
20484924 |
2010 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL13 SNP rs1800925 and IL4R SNP 1801275 did not demonstrate overall associations with AR.
|
21309855 |
2011 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 SNPs rs1881457(-1512) and rs1800925(-1111) were associated with better FEV(1) and FEV(1)/FVC in asthmatics.
|
19796199 |
2010 |
|
Rhinoconjunctivitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, a new pattern of biological interaction that affects the risk of rhinoconjunctivitis is described between SNP rs1800925 and smoking.
|
22023794 |
2011 |
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the rs1800925 T allele of the IL-13 gene is associated with worse pulmonary function in patients with IPF of Chinese Han ethnicity.
|
23549736 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analysis according to ethnicity, the T allele of rs1800925 was associated with an increased risk of COPD in Asians (OR = 1.88, 95% CI: 1.23-2.87, Pz = .004) and Caucasians (OR = 1.30, 95% CI: 1.01-1.67, Pz = .041), respectively.
|
29381928 |
2017 |