|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
On the other hand, the minor A alleles for rs762534 and rs1800925 were not significantly associated with asthma risk.
|
29211635 |
2018 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses.
|
22222605 |
2012 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
No significant association was found between rs1800925 and asthma.
|
22053598 |
2011 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 SNPs rs1881457(-1512) and rs1800925(-1111) were associated with better FEV(1) and FEV(1)/FVC in asthmatics.
|
19796199 |
2010 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 C-1111T (rs1800925) was significantly associated with rhinitis and atopic phenotypes in rhinitis trios that were not affected by clinical asthma.
|
20484924 |
2010 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
Asthma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Although this SNP (rs1800925) was not associated with asthma exacerbations among all white children in CAMP, it was associated with increased risk of asthma exacerbations among children on inhaled corticosteroids (P = .02).
|
17561245 |
2007 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
|
29687183 |
2018 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of the present study was to conduct a meta-analysis assessing the possible association of IL-13 SNP rs1800925 with allergic rhinitis risk.
|
22750299 |
2012 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis.
|
22023794 |
2011 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL13 SNP rs1800925 and IL4R SNP 1801275 did not demonstrate overall associations with AR.
|
21309855 |
2011 |
|
Allergic rhinitis (disorder)
|
|
0.050 |
GeneticVariation
|
BEFREE |
A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043).
|
18037162 |
2008 |
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation
|
BEFREE |
An additional SNP, rs1800925, was genotyped only in the PsA and PsC groups.
|
21613309 |
2011 |
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation
|
BEFREE |
Both SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1 × 10(-5) OR 1.33, rs20541 ptrend = 8.0 × 10(-4) OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.
|
21349879 |
2011 |
|
Arthritis, Psoriatic
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined the association between IL13 polymorphisms, smoking, and PsA in two Ps sample sets genotyped for rs1800925, rs20541, and rs848.
|
19554022 |
2009 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analysis according to ethnicity, the T allele of rs1800925 was associated with an increased risk of COPD in Asians (OR = 1.88, 95% CI: 1.23-2.87, Pz = .004) and Caucasians (OR = 1.30, 95% CI: 1.01-1.67, Pz = .041), respectively.
|
29381928 |
2017 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Tumor DNA was extracted from these biopsies and sequenced to analyze the rs1800925 polymorphism.
|
27167201 |
2016 |
|
Glioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs).
|
25472582 |
2015 |
|
Glioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that the IL13 rs20541 polymorphism contributes to susceptibility to cancer, especially for glioma; and the IL13 rs1800925 polymorphism may be associated with glioma risk.
|
23246181 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD.
|
24286397 |
2013 |
|
Eczema
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor TT genotype of the rs1800925 SNP and the minor AA genotype of the rs20541 SNP were significantly related to an increased risk of eczema: adjusted odds ratio for the TT genotype was 2.78 (95% confidence interval 1.22-6.30) and that for the AA genotype was 2.38 (95% confidence interval 1.35-4.18).
|
20975284 |
2011 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNPs superoxide dismutase 2 (SOD2) rs4880 (P=0.005) and interleukin-13 (IL13) rs1800925 (P=0.0008) were significantly associated with tumor response to chemoradiation.
|
20644561 |
2011 |
|
Eczema
|
|
0.020 |
GeneticVariation
|
BEFREE |
We could not find evidence for an interaction between SNP rs1800925 and smoking with regard to eczema.
|
22013915 |
2011 |