|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
We performed a genetic association analysis in several KD subgroups categorized by clinical characteristics using the KD-associated variants of the B lymphoid tyrosine kinase (<i>BLK</i>; rs6993775) and Fc gamma receptor II a (<i>FCGR2A</i>; rs1801274) in a large number of case (n=1,011) and control (n=4,533) samples.
|
30468029 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
Now, we show in 1,028 European KD patients that the <i>FCGR2C</i>-ORF haplotype, although nearly absent in Asians, was more strongly associated with susceptibility to KD than rs1801274 in Europeans.
|
30949161 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
In a meta-analysis with 1,461 cases and 5,302 controls, a very strong association of KD with the nonsynonymous SNP rs1801274 (p.His167Arg, previously assigned as p.His131Arg) in FCGR2A was confirmed in males (OR = 1.48, P = 1.43 × 10-7), but not in the females (OR = 1.17, P = 0.055).
|
28886140 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
GWASCAT |
The present study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only.
|
28886140 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
Compared with their respective wild type counterparts, rs1801274 AG+GG genotypes and rs3818298 TC+CC genotypes were nominally associated with the reduced risk of KD (OR = 0.77, 95% CI = 0.59-0.99, P = 0.045; OR = 0.74, 95% CI = 0.56-0.98, P = 0.038).
|
25645453 |
2015 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
These results further confirm that rs1801274 in the FCGR2A gene is significantly associated with increased risk of KD.
|
25093412 |
2014 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
Significant susceptibility to CALs was found in KD patients with high-risk genotypes at both rs1801274 and rs2857151.
|
23456091 |
2013 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
BEFREE |
We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease.
|
22446962 |
2012 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
BEFREE |
The minor homozygote (CC) of FCGR2A (rs1801274) may contribute to decrease the susceptibility to UC and the TC haplotype formed by FCGR2A (rs1801274 and rs511278) may increase the risk of UC in the Chinese population.
|
30260678 |
2018 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
BEFREE |
This association seemed to be modified by the UC susceptibility locus, rs1801274, a coding variant in the FcγRIIA gene (Pinteraction = 7.00E-05).
|
28604414 |
2017 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Six CSE-induced genes in DLD-1 cells were located in UC-susceptibility loci, including HSPA6 (rs1801274).
|
26826017 |
2016 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASDB |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
19915573 |
2009 |
|
Ulcerative Colitis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
19915573 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |