|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs.
|
25502405 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding.
|
17624182 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet.
|
22102511 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism in exon B of peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes.
|
14981210 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability in insulin sensitivity.
|
19645740 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR.
|
15860437 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin.
|
19733160 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have determined the Pro12Ala variant frequency in 370 nondiabetic Mexican Mestizo subjects and in five Mexican Amerindian groups and have investigated its possible association with lipid metabolism, insulin serum levels, and obesity in three of these populations.
|
17985660 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance.
|
17408525 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease.
|
26243686 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the combination of the rs2282440-SDC3T/T genotype with the rs1801282-peroxisome proliferator-activated receptor-gamma2 gene (PPARγ2) G carrier genotype was strongly associated with obesity (OR=6.77).
|
27515755 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034).
|
24200052 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat.
|
16777151 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes.
|
25342491 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers.
|
30122193 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype.
|
9918859 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations.
|
17439324 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%.
|
27442659 |
2016 |