|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype.
|
9918859 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9.
|
10873398 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
|
11158005 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that P12A may be a genetic marker indicating risk for obesity persisting into adolescence.
|
11591408 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional single nucleotide polymorphism (SNP) that predicts a proline to alanine substitution (Pro12Ala) within the coding region of this gene has previously been associated with obesity and type 2 diabetes in several populations.
|
12829658 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the higher frequency of the C-->T substitution in exon 6 of the PPAR-gamma gene in PCOS women suggests that it plays a role in the complex pathogenetic mechanism of obesity in PCOS, whereas the Pro(12)Ala polymorphism does not seem to affect BMI in PCOS women.
|
14671186 |
2003 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism in exon B of peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes.
|
14981210 |
2004 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results showed that the Pro12Ala polymorphism is not associated with childhood or adult obesity in the French Caucasian population.
|
15784141 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR.
|
15860437 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m2) nondiabetic subjects.
|
16231017 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat.
|
16777151 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance.
|
17408525 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations.
|
17439324 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding.
|
17624182 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.
|
17898990 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have determined the Pro12Ala variant frequency in 370 nondiabetic Mexican Mestizo subjects and in five Mexican Amerindian groups and have investigated its possible association with lipid metabolism, insulin serum levels, and obesity in three of these populations.
|
17985660 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory results.
|
18250615 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity.
|
18280041 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability in insulin sensitivity.
|
19645740 |
2009 |