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ACQUIRED IMMUNODEFICIENCY SYNDROME, SLOW PROGRESSION TO
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|
0.700 |
CausalMutation
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CLINVAR |
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Myasthenia Gravis
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|
0.020 |
GeneticVariation
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BEFREE |
Rs2107356 and rs1805010 were found to be associated with adult thymoma associated MG, and rs1801275 was found to be associated with adult non-thymoma AChR-Ab positive MG. We did not found association between IL-4Rα polymorphism and the severity of MG. Genetic variations of IL-4Rα were found associated with the susceptibility of MG in Chinese Han population.
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30042722 |
2018 |
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Diffuse Large B-Cell Lymphoma
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|
0.020 |
GeneticVariation
|
BEFREE |
In relation to OS, a highly significant interaction was observed in DLBCL for IL4RA (rs1805010) * IL10 (rs1800890) (HR = 0.11 (0.02-0.50)).
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26448050 |
2015 |
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Rheumatoid Arthritis
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|
0.020 |
GeneticVariation
|
BEFREE |
The data indicate that the rs1805010 minor allele contributes to increased Th17 cell frequency, enhanced clinical activity, and accelerated radiographic progression in RA by rendering CD4 T cells from RA patients insensitive to the attenuating effect of IL-4 on Th17 cell development.
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24782180 |
2014 |
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Asthma
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|
0.020 |
GeneticVariation
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BEFREE |
To investigate whether the single-nucleotide polymorphisms (SNPs) Ile75Val and Gln576Arg in the IL4RA gene, -33C>T in the IL4 gene, and Gly237Glu in the FCER1B gene contribute to the development and severity of atopic bronchial asthma in Russian patients from Moscow.
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22533235 |
2012 |
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Myasthenia Gravis
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|
0.020 |
GeneticVariation
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BEFREE |
Although the distribution of the S503P and Q576R polymorphisms did not differ significantly between the groups, the frequency of the GG rare homozygote genotype of the I75V polymorphism was significantly higher in patients with myasthenia gravis.
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22119518 |
2012 |
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Rheumatoid Arthritis
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|
0.020 |
GeneticVariation
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BEFREE |
To determine whether IL4R single-nucleotide polymorphisms (SNPs) rs1805010 (I50V) and rs1801275 (Q551R), which have been associated with disease severity in rheumatoid arthritis (RA) patients of European ancestry, relate to the presence of rheumatoid nodules and radiographic erosions in African Americans.
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20444266 |
2010 |
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Asthma
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|
0.020 |
GeneticVariation
|
BEFREE |
One SNP in IL4RA1 [rs1805010(I75V)] was associated with asthma severity, and several IL13 SNPs showed borderline significance.
|
19796199 |
2010 |
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Diffuse Large B-Cell Lymphoma
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|
0.020 |
GeneticVariation
|
BEFREE |
These data support the role for host germline gene variations of immunologically important factors like the IL4R I75V gene variation to predict the survival in DLBCL patients.
|
19515749 |
2009 |
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Malignant neoplasm of kidney
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|
0.010 |
GeneticVariation
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BEFREE |
I75V G allele carriers were associated with a decreased risk of renal cancer (dominant model = 0.71, 95%CI = 0.57-0.89, heterozygote comparison: OR = 0.69, 95%CI = 0.55-0.87).
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23464436 |
2012 |
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Primary malignant neoplasm
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|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that Q576R, I75V and S503P may be associated with a decreased cancer risk for certain types of cancers and in some specific ethnic groups.
|
23464436 |
2012 |
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Renal carcinoma
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|
0.010 |
GeneticVariation
|
BEFREE |
I75V G allele carriers were associated with a decreased risk of renal cancer (dominant model = 0.71, 95%CI = 0.57-0.89, heterozygote comparison: OR = 0.69, 95%CI = 0.55-0.87).
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23464436 |
2012 |
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Malignant Neoplasms
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|
0.010 |
GeneticVariation
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BEFREE |
Our results suggest that Q576R, I75V and S503P may be associated with a decreased cancer risk for certain types of cancers and in some specific ethnic groups.
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23464436 |
2012 |
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Early Rheumatoid Arthritis
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|
0.010 |
GeneticVariation
|
BEFREE |
Two IL4R SNPs, rs1805010 and rs1801275, were genotyped in 749 patients from the Consortium for Longitudinal Evaluation of African-Americans with Early Rheumatoid Arthritis (CLEAR) registries.
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20444266 |
2010 |
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Superficial ulcer
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|
0.010 |
GeneticVariation
|
BEFREE |
To determine whether IL4R single-nucleotide polymorphisms (SNPs) rs1805010 (I50V) and rs1801275 (Q551R), which have been associated with disease severity in rheumatoid arthritis (RA) patients of European ancestry, relate to the presence of rheumatoid nodules and radiographic erosions in African Americans.
|
20444266 |
2010 |
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Rheumatoid Nodule
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|
0.010 |
GeneticVariation
|
BEFREE |
We found that IL4R SNPs, rs1801275 and rs1805010, are associated with rheumatoid nodules in autoantibody-positive African-American RA patients with at least one HLA-DRB1 allele encoding the SE.
|
20444266 |
2010 |