|
Asthma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results indicate that rs1805011 polymorphism of IL4Rα gene seems to influence allergy risk, especially mild asthma and atopic dermatitis predisposition in Polish children.
|
26426602 |
2016 |
|
Asthma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Five SNPs, rs3733475A/C (IRF2), rs2069832A/G (IL6), rs2012075G/A (IFNGR2) and rs1400656G/A (STAT4) and rs1805011C/A (IL4RA) were found to be associated with asthma in family based as well as in case-control analyses (P=0.002, P=0.001, P=0.004, P=0.003 and P=0.001, respectively).
|
25994869 |
2015 |
|
Asthma
|
|
0.040 |
GeneticVariation
|
BEFREE |
An individual with an AA genotype in rs1805011 of the IL4R gene was less likely to suffer from asthma compared to the other two genotypes.
|
23924473 |
2013 |
|
Asthma
|
|
0.040 |
GeneticVariation
|
BEFREE |
IL4R Glu375Ala (rs1805011) and Ser411Leu (rs1805013) were associated with asthma in the asthma case-control population.
|
20484924 |
2010 |
|
Eczema
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that rs1805011 polymorphism of IL4Rα gene seems to influence allergy risk, especially mild asthma and atopic dermatitis predisposition in Polish children.
|
26426602 |
2016 |
|
Dermatitis, Atopic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that rs1805011 polymorphism of IL4Rα gene seems to influence allergy risk, especially mild asthma and atopic dermatitis predisposition in Polish children.
|
26426602 |
2016 |
|
Eczema
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significant associations between SNPs rs1805011 and rs1805015 and eczema were reported in women who had never smoked, but not in those who had ever smoked; the multiplicative interactions, however, were not significant.
|
23480403 |
2013 |
|
Dermatitis, Atopic
|
|
0.020 |
GeneticVariation
|
BEFREE |
We determined the genotype with regard to polymorphisms in the genes for IL-4 and the IL-4 receptor alpha chain (- 589C/T of IL-4; Ile50Val, Ala375Glu and Arg551Gln of IL-4 receptor alpha chain) in patients with atopic eczema using the fluorogenic 5' nuclease assay.
|
11678851 |
2001 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
Several missense variants were found associated with CHB, including p.E226K in PVR (poliovirus receptor), p.E400A and p.C431R in IL4R (interleukin 4 receptor).
|
29287219 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations of the IL-4Rα E400A genotypes and high density lipoprotein-cholesterol (HDL-C) levels among control individuals (p=0.007), as well as among the T2DM patients (p=0.029), were observed.
|
22633285 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant alleles at the non-synonymous SNPs (rs1805011 (E400A), rs1805012 (C431R), and rs1801275 (Q576R)), which are in strong linkage disequilibrium, were negatively associated with T1D risk.
|
19956098 |
2009 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 6 loci (IL-13 C-1112T, IL-13 C1923T, IL-4 C-590T, IL-4RA 175V, FcER1B E237G and 12-ADR Q27E) make little contribution to the development of asthma in children of Chinese Han nationality.
|
19862939 |
2009 |
|
Adult atopic dermatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Glu375Ala and Cys406Arg also showed no association with AD.
|
10809862 |
2000 |