|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) To determine the allele and genotype frequency of the Pro12Ala PPARgamma2 amino acid variant in a Polish population; (2) To search for the association of the Pro12Ala polymorphism with T2DM in the examined population.
|
14581147 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus.
|
12218380 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid.
|
16920849 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala mutation decreases PPARG activity and resistance to NIDDM.
|
22937051 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes.
|
12643137 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional single nucleotide polymorphism (SNP) that predicts a proline to alanine substitution (Pro12Ala) within the coding region of this gene has previously been associated with obesity and type 2 diabetes in several populations.
|
12829658 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the PPARG gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced fluid retention and edema in patients with type 2 diabetes.
|
16822823 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
|
23559865 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although cross-sectional studies have associated the Pro12Ala polymorphism of PPARG with type 2 diabetes, prospective studies offer more opportunities to investigate genetic variants.
|
16567542 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin (P = 0.004 under an additive model for rs2144908; and P = 0.001 under a dominant model for rs2144908) after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala.
|
20079163 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although our data indicate that the PPARG2 gene variants, independently, have no association with type 2 diabetes mellitus, the 2-loci genotype analysis involving -1279G/A and Pro12Ala variants and the 3-loci haplotype analysis have shown a significant association with type 2 diabetes mellitus in this South Indian population.
|
19846173 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the study was carried out on a sufficiently large sample, the conclusions do not support a major role for the Pro12Ala substitution of the PPAR-gamma gene in the etiology of type 2 diabetes.
|
10389855 |
1999 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism.
|
16050954 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis.
|
11684868 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.
|
14730381 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conflicting evidence exists as to whether the Pro12Ala single nucleotide polymorphism of the type 2 diabetes susceptibility gene peroxisome proliferator-activated receptor gamma (PPARG) also confers risk for type 1 diabetes (T1D).
|
18466209 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
|
25974167 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
|
17213274 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes.
|
21833536 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four of the nine SNPs revealed a significant association with T2D; PPARG2 (Pro12Ala) [odds ratio (OR) 0.12; 95% confidence interval (CI) (0.03-0.52); p = 0.005], IGF2BP2 [OR 1.37; 95% CI (1.04-1.82); p = 0.027], TCF7L2 [OR 1.64; 95% CI (1.20-2.24); p = 0.001] and FTO [OR 1.46; 95% CI (1.11-1.93); p = 0.007] after adjusting for age, sex and BMI.
|
18598350 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.
|
9425261 |
1997 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, our aim was to develop a low-cost method for the validation of PPARG (Pro12Ala, CCA>GCA) SNP (rs1801282) for its association with T2D.
|
25063576 |
2014 |